■ 学術論文／学会誌（計１６報）

  1. 1.Sakai K, Koyama N, Fukuda T, Mori Y, Onaka H, Tomoda H.

  2. Search method for inhibitors of staphyloxanthin production by Methicillin-resistant Staphylococcus

  3. aureus.

  4. Biol Pharm Bull 35(1):48-53 (2012)


  1. 2.Kaneko M, Matsuda D, Ohtawa M, Fukuda T, Nagamitsu T, Yamori T, Tomoda H.

  2. Potentiation of bleomycin in jurkat cells by fungal pycnidione.

  3. Biol Pharm Bull 35(1):18-28 (2012)


  1. 3.Matsumoto T, Hosoya T, Tomoda H, Shiro M, Shigemori H.

  2. Palmaenones A and B, two new antimicrobial chlorinated cyclopentenones from discomycete Lachnum palmae.

  3. Chem Pharm Bull 59(12):1559-1561 (2011)


  1. 4.Ugaki N, Yamazaki H, Uchida R, Omura S, Tomoda H.

  2. New isochaetochromin, an inhibitor of triacylglycerol synthesis in mammalian cells, produced by

  3. Penicillium sp. FKI-4942: II. Structure elucidation.

  4. J Antibiot 65(1):21-24 (2011)


  1. 5.Ugaki N, Matsuda D, Yamazaki H, Nonaka K, Masuma R, Omura S, Tomoda H.

  2. New isochaetochromin, an inhibitor of triacylglycerol synthesis in mammalian cells, produced by Penicillium sp. FKI-4942: I. Taxonomy, fermentation, isolation and biological properties.

  3. J Antibiot 65(1):15-19 (2011)


  1. 6.Doi T, Muraoka T, Ohshiro T, Matsuda D, Yoshida M, Takahashi T, Omura S, Tomoda H.

  2. Conformationally restricted analog and biotin-labeled probe based on beauveriolide III.

  3. Bioorg Med Chem Lett 22(1):696-699 (2011)


  1. 7.Koyama N, Tokura Y, Takahashi Y, Tomoda H.

  2. New cyslabdans B and C, potentiators of imipenem activity against methicillin-resistant

  3. Staphylococcus aureus produced by Streptomyces sp. K04-0144.

  4. Acta Pharmaceutica Sinica B 1:236-239 (2011)


  1. 8.Odani A, Ishihara K, Ohtawa M, Tomoda H, Omura S, Nagamitsu T.

  2. Total synthesis of pyripyropene A

  3. Tetrahedron 67:8195-8203 (2011)


  1. 9.Yamamuro D, Uchida R, Takahashi Y, Masuma R, Tomoda H.

  2. Screening for microbial metabolites affecting phenotype of Caenorhabditis elegans.

  3. Biol Pharm Bull 34(10):1619-1623 (2011)


  1. 10.Urano E, Kuramochi N, Ichikawa R, Murayama SY, Miyauchi K, Tomoda H, Takebe Y, Nermut M,

  2. Komano J, Morikawa Y.

  3. Novel postentry inhibitor of human immunodeficiency virus type 1 replication screened by yeast membrane-associated two-hybrid system.

  4. Antimicrob Agents Chemother 55(9):4251-4260 (2011)


  1. 11.Mori M, Morimoto H, Kim Y P, Ui H, Nonaka K, Masuma R, Sakamoto K, Kita K, Tomoda H, Shiomi

  2. K, Omura S.

  3. Ukulactones A and B, new NADh-fumarate reductase inhibitors produced by Penicillium sp. FKI-

  4. 3389.

  5. Tetrahedron 67:6582-6586 (2011)


  1. 12.Kawamoto K, Yamazaki H, Ohte S, Masuma R, Uchida R, Tomoda H.

  2. Production of monapinones by fermentation of the dinapinone-producing fungus Penicillium pinophilum FKI-3864 in a seawater-containing medium.

  3. J Antibiot 64:503-508 (2011)


  1. 13.Ohte S, Matsuda D, Uchida R, Nonaka K, Masuma R, Omura S, Tomoda H.

  2. Dinapinones, novel inhibitors of triacylglycerol synthesis in mammalian cells, produced by Penicillium pinophilum FKI-3864.

  3. J Antibiot 64:489-494 (2011)


  1. 14.Ohshiro T, Matsuda D, Sakai K, Degirolamo C, Yagyu H, Rudel LL, Omura S, Ishibashi S, Tomoda

  2. H.

  3. Pyripyropene A, an Acyl-Coenzyme A: Cholesterol acyltransferase 2-selective inhibitor, attenuates

  4. hypercholesterolemia and atherosclerosis in murine models of hyperlipidemia.

  5. Arterioscler Thromb Vasc Biol 31(5):1108-1115 (2011)


  1. 15.Ohte S, Shin M, Sasanuma H, Yoneyama K, Akita M, Ikebuchi K, Jimi E, Maruki Y, Matsuoka M,

  2. Namba A, Tomoda H, Okazaki Y, Ohtake A, Oda H, Owan I, Yoda T, Furuya H, Kamizono J, Kitoh

  3. H, Nakashima Y, Susami T, Haga N, Komori T, Katagiri T.

  4. A novel mutation of ALK2, L196P, found in the most benign case of fibrodysplasia ossificans

  5. progressiva activates BMP-specific intracellular signaling equivalent to a typical mutation, R206H.

  6. Biochem Biophys Res Commun 407(1):213-218 (2011)


  1. 16.Yamamoto N, Fujii H, Imaide S, Hirayama S, Nemoto T, Inokoshi J, Tomoda H, Nagase H.

  2. Synthesis of (-)-homogalanthamine from naltrexone.

  3. J Org Chem 76(7):2257-2260 (2011)




■ 学術論文／総説（計３報）

  1. 1.Tomoda H, Sekimizu K.

  2. Recent advance in research of new anti-infectious agents - discovery chemical biology and

  3. development -.

  4. Yakugaku Zasshi 132(1):35-36 (2012)


  1. 2.Tomoda H.

  2. Mode of Action of Microbial Anti-MRSA Agents.

  3. Yakugaku Zasshi 132(1):37-44 (2012)


  1. 3.Ohshiro T, Tomoda H.

  2. Isoform-specific inhibitors of ACATs: recent advances and promising developments.

  3. Future Med Chem 3(16):2039-2061 (2011)



■ 特別講演／招待講演（計５題）

  1. 1.Tomoda H.

  2. Fungal dinapinones, Inhibitors of triacylglycerol accumulation in mammalian cells.

  3. VIIth US‐JAPAN SEMINAR (Okinawa, Japan) 2011.12.12


  1. 2.Tomoda H.

  2. Antiatherosclerotic activity of fungal pyripypopene A and its derivatives in mouse models.

  3. International Union of Microbiologocal Societies 2011 Congress (Sapporo, Japan)  2011.9.7


  1. 3.Tomoda H.

  2. Fungal dinapinones and monapinones, inhibitors of triacylglycerol synthesis in mammalian cells.

  3. 2011 International Symposium & Annual Meeting（Gyeongju, Korea）2011.6.23


  5. 4.Tomoda H.

  6. Mechanism of action of new anti-infectious agents from microorganisms.

  7. The Uehara Memorial Foundation Symposium 2011 (Tokyo, Japan) 2011.6.8


  1. 5.Tomoda H.

  2. Mechanism of action of cyslabdan, a potentiator of imipenem activity against MRSA.

  3. Inaugural Metting of Bergey’s International Society for Microbial Systematics（Beijing, China）

  4. 2011.5.22




■ 学会発表／シンポジウム（計１題）

  1. 1.Fukuda T.

  2. Discovering new bioactive products from terrestrial and marine microorganisms.

  3. The 6th Korea-Japan Chemical Biology Symposium (Sapporo, Japan) 2012.1.27



■ 学会発表／一般講演（計１９題）

  1. 1.宮﨑秀俊, 内田龍児, 山口裕一, 供田 洋

  2. 温泉由来真菌 Penicillium sp. BF0003 株の二次代謝産物生産能の解析

  3. 日本薬学会第132年会（札幌）2012. 3.31


  1. 2.坂井謙斗, 小山信裕, 福田隆志, 供田 洋

  2. MRSA の生産する黄色色素生成阻害物質の探索系の構築

  3. 日本薬学会第132年会（札幌）2012. 3.31


  1. 3.福田隆志, 坂井謙斗, 供田 洋

  2. 子実体 Tylopilus eximius 由来 MRSA の生産する黄色色素生成阻害物質に関する研究

  3. 日本薬学会第132年会（札幌）2012. 3.31


  1. 4.内田龍児, 近藤あり子, 野中健一, 増間碌郎, 供田 洋

  2. 真菌 Simplicillium sp. FKI-4981 株が生産する新規 amphotericin B 活性増強物質に関する研究

  3. 日本薬学会第132年会（札幌）2012. 3.30


  1. 5.西尾和毅, 坂井謙斗, 福田隆志, 供田 洋

  2. 真菌由来 xanthone 類による MRSA の生産する黄色色素生成阻害活性に関する研究

  3. 日本薬学会第132年会（札幌）2012. 3.30


  1. 6.猪腰淳嗣, 重田直樹, 野中健一, 増間碌郎, 供田 洋

  2. 真菌FKI-4533株が生産するウンデカプレニル２リン酸合成酵素阻害物質に関する研究

  3. 日本薬学会第132年会（札幌）2012. 3.30


  1. 7.小林大祐, 小西元美, 長野 真, 川口未央, 安原 義, 供田 洋, 秋澤俊史

  2. Trichodermaの産生するマトリックスメタロプロテアーゼ阻害物質の検索

  3. 日本薬学会第132年会（札幌）2012. 3.29


  1. 8.川口未央, 猪腰淳嗣, 安原 義, 供田 洋

  2. Monapinone A 二量体化酵素 の精製と性質

  3. 日本薬学会第132年会（札幌）2012. 3.29


  1. 9.小林啓介, 松田大介, 大城太一, 供田 洋

  2. Bufalin が有するマウスマクロファージ内脂肪滴蓄積阻害活性の作用機序解析

  3. 日本薬学会第132年会（札幌）2012. 3.29


  1. 10.菱沼裕介, 高木永治, 供田 洋, 長光 亨

  2. Cyslabdan の合成研究

  3. 日本薬学会第132年会（札幌）2012. 3.29


  1. 11.Inokoshi J, Miyake M, Shimizu Y, Tomoda H.

  2. Analysis of essential amino acids in lasso peptide lariatins for anti-mycobacterial activity

  3. by single amino acid substitution.

  4. The 6th Korea-Japan Chemical Biology Symposium（Sapporo）2012.1.27


  1. 12.Sakai K, Fukuda T, Koyama N, Tomoda H.

  2. Inhibition of MRSA yellow pigment production by Citridone A.

  3. The 6th Korea-Japan Chemical Biology Symposium（Sapporo）2012.1.27


  1. 13.Koyama N, Tokura Y, Tomoda H.

  2. Mechanism of action of cyslabdan, a potentiator of β-lactam drug activity against MRSA.

  3. The 6th Korea-Japan Chemical Biology Symposium（Sapporo）2012.1.27


  1. 14.Kawaguchi M, inokoshi J, Yasuhara T, Tomoda H.

  2. Purification and characterization of monapinone a dimerizing enzyme

  3. The 6th Korea-Japan Chemical Biology Symposium（Sapporo）2012.1.27


  1. 15.Fukuda T, Fenical W, Tomoda H.

  2. Chemical study of secondary metabolites produced by Penicillium sp. FKI‐1938 isolated at Ishigakijima

  3. VIIth US‐JAPAN SEMINAR (Okinawa, Japan) 2011.12.12



  1. 16.Fukuda T, Tomoda H.

  2. Tylopilusins, New di-phenolics from fruit bodies of Tylopilus eximius

  3. 2011 American Society of Phamacognosy Annual Meeting (San Diego, USA) 2011.7.31


  1. 17.Sakai K, Tomoda H.

  2. Microbial anthraquinones inhibit staphyloxanthin production by MRSA

  3. Inaugural Metting of Bergey’s International Society for Microbial Systematics（Beijing, China）

  4. 2011.5.22


  1. 18.Yamamuro D, Tomoda H.

  2. Screening for microbial metabolites affecting phenotype of Caenorhabditis elegans

  3. Inaugural Metting of Bergey’s International Society for Microbial Systematics（Beijing, China）

  4. 2011.5.22　＊Best poster 賞


  1. 19.Fukuda T, Tomoda H.

  2. Chemical study of citridones and citrinamides produced by Penicillium sp. FKI-1938

  3. Inaugural Metting of Bergey’s International Society for Microbial Systematics（Beijing, China）

  4. 2011.5.22


■学内発表／講演（計３題）

  1. 1.猪腰淳嗣, 供田 洋

  2. 投げ縄構造を有するペプチド lariatin の生合成に関する研究 – LarCの構造解析 –

  3. 第14回北里微生物アカデミー研究集会（相模原）2011.8.23


  1. 2.小山信裕, 供田 洋

  2. 真菌の生産する新しい抗結核ペプチド calpinavtam の研究

  3. 第14回北里微生物アカデミー研究集会（相模原）2011.8.23


  1. 3.Tomoda H.

  2. Microbial inhibitors of lipid metabolism

  3. Pukyong National University（Busan, Korea）2011.6.21



 

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