学術論文

Kumagai T., Kozakai.Y., Ishino T., Yajima Y., Nakagawa Y. and Imai H.: Nrf2 up-regulates the induction of acidic sphingomyelinase by electrophiles. J. Biochem. 158 : 127-137, 2015

Kumagai T., Usami H., Matsukawa N., Nakashima F., Chikazawa M., Shibata T., Noguchi N., and Uchida K.: Functional interaction between cyclooxygenase and p53 in response to an endogenous electrophile. Redox Biol. 4 : 74-86, 2015.

Kumagai T., Ishino T., and Nakagawa Y.: Acidic sphingomyelinase induced by electrophiles promotes proinflammatory cytokine production in human bladder carcinoma ECV-304 cells. Arch. Biochem. Biophys. 519 : 8-16, 2012.

Sakaue M., Mori N., Okazaki M., Ishii M., Inagaki Y., Iino Y., Miyahara K., Yamamoto M.,Kumagai T., Hara S., and Yamamoto M.,: Involvement of independent mechanism upon poly(ADP-ribose) polymerase (PARP) activation in methylmercury cytotoxicity in rat cerebellar granule cell culture. J.Neurosci. Res. 86 : 3427-3434, 2008.

Miyoshi N, Naniwa K, Kumagai T., Uchida K, Osawa T, and Nakamura Y. : Alpha-tocopherol-mediated caspase-3 up-regulation enhances susceptibility to apoptotic stimuli. Biochem Biophys Res Commun. 334 : 466-73, 2005.

Usami H, Kusano Y, Kumagai T., Osada S, Itoh K, Kobayashi A, Yamamoto M, and Uchida K. : Selective induction of the tumor marker glutathione S-transferase P1 by proteasome inhibitors. J Biol Chem. 280 :25267-76, 2005.

Kumagai T., Matsukawa N., Kaneko Y., Kusumi Y., Mitsumata M., and Uchida K.: A lipid peroxidation-derived inflammatory mediator: identification of 4-hydroxy-2-nonenal as a potential inducer of cyclooxygenase-2 in macropharges. J. Biol. Chem. 279 : 48389-48396, 2004.

Feng Q.,Kumagai T., Nakamura Y., Uchida K. and Osawa T.:Correlation of antimutagenic activity and suppression of CYP1A with the lipophilicity of alkyl gallates and other phenolic compounds. Mutant. Res. 537 : 101-108, 2003.

Nakamura Y.,Kumagai T., Yoshida C., Naito Y., Miyamoto M., Ohigashi H., Osawa T. and Uchida, K.: Pivotal role of electrophilicity in glutathione-S-transferase induction by tert-butylhydroquinone. Biochemistry 42 : 4300-4309, 2003.

Feng Q., Kumagai T., Nakamura Y., Uchida K. and Osawa T.: Induction of cytochrome P4501A1 by autoclavable culture medium change in HepG2 cells. Xenobiotica. 32 : 1033-1043, 2002.

Kondo M., Shibata T., Kumagai T., Osawa T., Shibata N., Kobayashi M., Sasaki S., Iwata M., Noguchi N. and Uchida K.: 15-Deoxy-Delta(12,14)-prostaglandin J(2): the endogenous electrophile that induces neuronal apoptosis. Proc. Natl. Acad. Sci. U S A. 99 : 7367-7372, 2002.

Kumagai T., Nakamura Y., Osawa T. and Uchida K.: Role of p38 mitogen-activated protein kinase in the 4-hydroxy-2-nonenal-induced cyclooxygenase-2 expression. Arch. Biochem. Biophys. 397 : 240-245, 2002.

Nakamura Y., Feng Q., Kumagai T., Torikai K., Ohigashi H., Osawa T., Noguchi N., Niki E. and Uchida K.: Ebselen, a glutathione peroxidase mimetic seleno-organic compound, as a multifunctional antioxidant. Implication for inflammation-associated carcinogenesis. J. Biol. Chem. 277 : 2687-2694, 2002.

Morimitsu Y., Nakagawa Y., Hayashi K., Fujii H., Kumagai T., Nakamura Y., Osawa T., Horio F., Itoh K., Iida K., Yamamoto M. and Uchida K.: A sulforaphane analogue that potently activates the Nrf2-dependent detoxification pathway. J. Biol. Chem. 277 : 3456-3463, 2002.

Feng Q.,Kumagai T., Torii Y., Nakamura Y., Osawa T. and Uchida K.: Anticarcinogenic antioxidants as inhibitors against intracellular oxidative stress. Free Radic. Res. 35 : 779-788, 2001.

Minekura H., Kumagai T.., Kawamoto Y., Nara F. and Uchida K.: 4-Hydroxy-2-nonenal is a powerful endogenous inhibitor of endothelial response. Biochem. Biophys. Res. Commun. 282 : 557-561, 2001.

Kondo M., Oya-Ito T., Kumagai T., Osawa T. and Uchida K.: Cyclopentenone prostaglandins as potential inducers of intracellular oxidative stress. J. Biol. Chem. 276 : 12076-12083, 2001.

Kumagai T., Kawamoto Y., Nakamura Y., Hatayama I., Satoh K., Osawa T. and Uchida K.: 4-Hydroxy-2-nonenal, the End Product of Lipid Peroxidation, Is a Specific Inducer of Cyclooxygenase-2 Gene Expression. Biochem. Biophys. Res. Commun. 273 : 437-441, 2000.

Kawamoto Y., Nakamura Y., Naito Y., Torii Y.,Kumagai T., Osawa T., Ohigashi H., Satoh K., Imagawa M. and Uchida K.: Cyclopentenone prostaglandins as potential inducers of phase II detoxification enzymes 15-deoxy-Delta(12,14)-prostaglandin J2-induced expression of glutathione S-transferases. J. Biol. Chem. 275 : 11291-11299, 2000.

Kumagai T., Yokoyama H., Goto A., Hirose J., Kadowaki T., Narita H. and Kitagawa Y.: Screening for Drosophila proteins with distinct expression patterns during development by use of monoclonal antibodies. Biosci. Biotechnol. Biochem. 64 : 24-8, 2000.

Suzuki H., Kumagai T., Sugiura T. and Goto A.: Increase in intracellular hydrogen peroxide and upregulation of a nuclear respiratory gene evoked by impairment of mitochondrial electron transfer in human cells. Biochem. Biophys. Res. Commun. 249 : 542-5, 1998.

総説

Imai H., Matsuoka M., Kumagai T., Sakamoto T., and Koumura T.: Lipid peroxidation-dependent cell death regulation by GPx4 and ferroptosis. Curr. Top. Microbiol. Immunol. 403 : 143-170, 2017.

Uchida K. and Kumagai T.: 4-hydroxy-2-nonenal as a COX-2 inducer. Mol.Aspects Med. 24 : 213-218, 2003.

学会発表

SMS2によるリポキシトーシスの抑制機構の解析
熊谷 剛
第2回 細胞死コロキウム 2021年11月18日

SMS2によるリポキシトーシス抑制機構の解析
安里 成美, 米山 昌吾, 熊谷 剛, 今井 浩孝
フォーラム2021 衛生薬学・環境トキシコロジー 2021年9月10日

リポキシトーシスにおけるCyp4x1の機能の解析
川野 みなみ, 高田 真悠子, 藤野 真里奈, 熊谷 剛, 今井 浩孝
フォーラム2021 衛生薬学・環境トキシコロジー 2021年9月10日

重水素型酸化リン脂質を用いた新たな酸化資質代謝系と意義
熊谷 剛, 今井 浩孝
第73回日本酸化ストレス学会・第20回日本NO学会合同学術集会 2020年10月7日

SMS2によるリポキシトーシスの抑制機構の解析
熊谷 剛, 今井 浩孝
フォーラム2020 衛生薬学・環境トキシコロジー 2020年9月4日

酸化リン脂質依存的に発現誘導される遺伝子群のリポキシトーシスに対する機能の解析
熊谷 剛, 廣田 里奈, 大原 理沙, 今井 浩孝
日本薬学会第140年会 2020年3月