2001
A
Sojourn in the synthesis and bioactivity of
diindolylalkanes. Chakrabarty,
M.; Basak, R.; Harigaya,
Y.
Heterocycles, 55(12), 2431-2447,
2001.
Synthesis
of
cis-
and
trans-5,8-dihydroxy-5,6,7,8-tetrahydro-1,4-naphthoquinone.
Arima,
S.;
Yamada (Konda), Y.; Takeda, K.; Takayanagi, H.;
Harigaya,
Y.
Chemical & Pharmaceutical bulletin, 49(10),
1340-1342,
2001.
Novel
synthesis of tetrahydro-2(1H)-quinolones
using Diels-Alder reactions of
1-arylsulfonyl-2(1H)-pyridones
having an electronwithdrawing group. Fujita,
R.; Watanabe, K.; Ikeura, W.; Ohtake, Y.; Hongo, H.;
Harigaya,
Y.;
Matsuzaki, H. Tetrahedron, 57, 8841-8850,
2001.
First
total synthesis of Mer-N5075A and a diastereomeric mixture
of
α
and
β-MAPI,
new HIV-I protease inhibitors from a species of
Streptmyces.
Konda,
Y.; Takahashi, Y.; Arima,
S.; Sato,
N.; Takeda, K.; Dobash, K.; Baba, M.; Harigaya,
Y.
Tetrahedron, 57, 4311-4321,
2001.
Electrophilic
substitution of indole. Part XIX. Synthesis of
15-(1H-indol-3-yl)-1,11,13-trimethyl-12,14-dioxa-9-azapentacyclo[11.3.1.1.0.0]octadeca-2(10),3,5,7-tetraene
from indole and acetylacetone. Banerji,
J.; Saha, M.; Dutta, U.; Mukherjee, P.; Chattterjee,
A.; Harigaya,
Y.;
Konda, Y.; Hatano, A. The Journal of the Indian Institute
of Science, 81(4), 165-168,
2001.
Determination
of Absolute Stereochemistries of Arisugacin F and Territrem
B, Novel Acetylcholinesterase. Handa,
M.; Sunazuka, T.; Nagai, K.; Kimura, R.; Otoguro, K,
Harigaya,
Y.;
Ōmura, S. Journal of Antibiotics, 54(4), 386-391,
2001.
Convergent
synthesis of arisugacin skeletons and their
acetylcholinesterase inhibitory activity.
Handa,
M.; Sunazuka, T.; Nagai, K.; Kimura, R.; Shirahata, T.;
Tian, Z-M.; Otoguro, K.; Harigaya,
Y.;
Ōmura, S. Journal of Antibiotics, 54(4), 382-385,
2001.
Synthesis
of Phenanthridones using Diels-Arder reactions of
4-substituted 2(1H)-quinolones acting as
dienophiles. Fujita,
R.; Watanabe, Y.; Yoshisuji, T.; Matsuzaki, H.;
Harigaya,
Y.;
Hongo, H. Chemical & Pharmaceutical Bulletin, 49(4),
407-412,
2001.
Total
synthesis of nafuredin, a selective NADH-fumarate reductase
inhibitor. Takano,
D.; Nagamitsu,
T.; Ui,
H.; Shiomi, K.; Yamaguchi, Y.; Masuma, R.; Kuwajima, I.;
Ōmura, S. Organic Letters, 3(15), 2289-2291,
2001.
Absolute
configuration of nafuredin, a new specific NADH-fumarate
reductase inhibitor. Takano,
D.; Nagamitsu,
T.; Ui,
H.; Shiomi, K.; Yamaguchi, Y.; Masuma, R.; Kuwajima, I.;
Ōmura, S. Tetrahedron Letters, 42(16), 3017-3020,
2001.
Nafuredin,
a novel inhibitor of NADH-fumarate reductase, produced by
Aspergillus niger FT-0554. Ui, H.;
Shiomi, K.; Yamaguchi, Y.; Masuma, R.; Nagamitsu,
T.;
Takano, D.; Sunazuka, T.; Namikoshi, M; Ōmura, S. Journal
of Antibiotics, 54, 234-238,
2001.
An
anthelmintic compound, nafuredin, shows selective
inhibition of complex I in helminth mitochondria.
Ōmura,
S.; Miyadera, H.; Ui, H.; Shiomi, K.; Yamaguchi, Y.;
Masuma, R.; Nagamitsu,
T.;
Takano, D.; Sunazuka,T.; Harder, A.; Kolbl, H.; Namikoshi,
M.; Miyoshi, H.; Sakamoto, K.; Kita, K. Proceedings of the
National Academy of Sciences of the United States of
America, 98, 60-62,
2001.