2021

【Original Article (English)】

Iwata H, Matsuo T, Mamada H, Motomura T, Matsushita M, Fujiwara T,Maeda K, Handa K. Prediction of Total Drug Clearance in Humans Using Animal Data: Proposal of a Multimodal Learning Method Based on Deep Learning. J Pharm Sci, 110, 1834-41 (2021)Link

Yoshida S, Honjo T, Iino K, Ishibe R, Leo S, Shimada T, Watanabe T, Ishikawa M,Maeda K, Kusuhara H, Shiraki N, Kume S. Generation of Human-Induced Pluripotent Stem Cell-Derived Functional Enterocyte-Like Cells for Pharmacokinetic Studies. Stem Cell Reports. 16, 295-308 (2021)Link

Deguchi S, Tsuda M, Kosugi K, Sakamoto A, Mimura N, Negoro R, Sano E, Nobe T,Maeda K, Kusuhara H, Mizuguchi H, Yamashita F, Torisawa YS, Takayama K. Usability of Polydimethylsiloxane-Based Microfluidic Devices in Pharmaceutical Research Using Human Hepatocytes. ACS Biomater Sci Eng. 7, 3648-57 (2021)Link

Narawa T, Narita Y, Hosokawa S andItoh TFunctional role of serine 318 of the proton-coupled folate transporter in methotrexate transport. Drug Metab Pharmacokinet, 41,100421 (2021)Link

Yoshikado T, Lee W, Toshimoto K, Morita K, Kiriake A, Chu X, Lee N, Kimoto E, Varma MVS, Kikuchi R, Scialis RJ, Shen H, Ishiguro N, Lotz R, Li AP,Maeda K, Kusuhara H, Sugiyama Y Evaluation of Hepatic Uptake of OATP1B Substrates by Short Term-Cultured Plated Human Hepatocytes: Comparison With Isolated Suspended Hepatocytes. J Pharm Sci, 110, 376-87 (2021)Link

Michiba K,Maeda K, Shimomura O, Miyazaki Y, Hashimoto S, Oda T, Kusuhara H. Usefulness of human jejunal spheroid-derived differentiated intestinal epithelial cells for the prediction of intestinal drug absorption in humans. Drug Metab Dispos, accepted (2021)

【Review Article (English)】

Maeda K, Hisaka A, Ito K, Ohno Y, Ishiguro A, Sato R and Nagai N. Classification of drugs for evaluating drug interaction in drug development and clinical management. Drug Metab Pharmacokinet, 41, 100414 (2021)Link

Hashimoto Y, Michiba K,Maeda Kand Kusuhara H. Quantitative prediction of pharmacokinetic properties of drugs in humans: recent advance in in vitro models to predict the impact of efflux transporters in the small intestine and blood–brain barrier. J Pharmacol Sci, in press (2021)Link

【Book chapter】

Maeda K. Application of a PBPK model incorporating the interplay between transporters and drug metabolizing enzymes for the precise prediction of drug toxicity. In: "Transporters and Drug-Metabolizing Enzymes in Drug Toxicity" (ed. by Li AP), Wiley, pp.429-454 (2021)

Maeda Kand Sugiyama Y. In vitro-in vivo scale-up of drug transport activities. In: "Drug Transporters" (ed. by Morris M and You G), Wiley, in press (2021)

前田和哉　がんの薬ってがんの部位だけに効かせることができるの？　「添付文書がちゃんと読める製剤学」（日本薬剤学会出版委員会編著、有馬英俊監修）、pp. 139-149、じほう (2021)

前田和哉　デジタルメディスンって何？　「添付文書がちゃんと読める製剤学」（日本薬剤学会出版委員会編著、有馬英俊監修）、pp. 180-186、じほう (2021)