Publication

Kumagai T., Kozakai.Y., Ishino T., Yajima Y., Nakagawa Y. and Imai H.: Nrf2 up-regulates the induction of acidic sphingomyelinase by electrophiles. J. Biochem. 158 : 127-137, 2015

Kumagai T., Usami H., Matsukawa N., Nakashima F., Chikazawa M., Shibata T., Noguchi N., and Uchida K.: Functional interaction between cyclooxygenase and p53 in response to an endogenous electrophile. Redox Biol. 4 : 74-86, 2015.

Kumagai T., Ishino T., and Nakagawa Y.: Acidic sphingomyelinase induced by electrophiles promotes proinflammatory cytokine production in human bladder carcinoma ECV-304 cells. Arch. Biochem. Biophys. 519 : 8-16, 2012.

Sakaue M., Mori N., Okazaki M., Ishii M., Inagaki Y., Iino Y., Miyahara K., Yamamoto M.,Kumagai T., Hara S., and Yamamoto M.,: Involvement of independent mechanism upon poly(ADP-ribose) polymerase (PARP) activation in methylmercury cytotoxicity in rat cerebellar granule cell culture. J.Neurosci. Res. 86 : 3427-3434, 2008.

Miyoshi N, Naniwa K, Kumagai T., Uchida K, Osawa T, and Nakamura Y. : Alpha-tocopherol-mediated caspase-3 up-regulation enhances susceptibility to apoptotic stimuli. Biochem Biophys Res Commun. 334 : 466-73, 2005.

Usami H, Kusano Y, Kumagai T., Osada S, Itoh K, Kobayashi A, Yamamoto M, and Uchida K. : Selective induction of the tumor marker glutathione S-transferase P1 by proteasome inhibitors. J Biol Chem. 280 :25267-76, 2005.

Kumagai T., Matsukawa N., Kaneko Y., Kusumi Y., Mitsumata M., and Uchida K.: A lipid peroxidation-derived inflammatory mediator: identification of 4-hydroxy-2-nonenal as a potential inducer of cyclooxygenase-2 in macropharges. J. Biol. Chem. 279 : 48389-48396, 2004.

Feng Q.,Kumagai T., Nakamura Y., Uchida K. and Osawa T.:Correlation of antimutagenic activity and suppression of CYP1A with the lipophilicity of alkyl gallates and other phenolic compounds. Mutant. Res. 537 : 101-108, 2003.

Nakamura Y.,Kumagai T., Yoshida C., Naito Y., Miyamoto M., Ohigashi H., Osawa T. and Uchida, K.: Pivotal role of electrophilicity in glutathione-S-transferase induction by tert-butylhydroquinone. Biochemistry 42 : 4300-4309, 2003.

Feng Q., Kumagai T., Nakamura Y., Uchida K. and Osawa T.: Induction of cytochrome P4501A1 by autoclavable culture medium change in HepG2 cells. Xenobiotica. 32 : 1033-1043, 2002.

Kondo M., Shibata T., Kumagai T., Osawa T., Shibata N., Kobayashi M., Sasaki S., Iwata M., Noguchi N. and Uchida K.: 15-Deoxy-Delta(12,14)-prostaglandin J(2): the endogenous electrophile that induces neuronal apoptosis. Proc. Natl. Acad. Sci. U S A. 99 : 7367-7372, 2002.

Kumagai T., Nakamura Y., Osawa T. and Uchida K.: Role of p38 mitogen-activated protein kinase in the 4-hydroxy-2-nonenal-induced cyclooxygenase-2 expression. Arch. Biochem. Biophys. 397 : 240-245, 2002.

Nakamura Y., Feng Q., Kumagai T., Torikai K., Ohigashi H., Osawa T., Noguchi N., Niki E. and Uchida K.: Ebselen, a glutathione peroxidase mimetic seleno-organic compound, as a multifunctional antioxidant. Implication for inflammation-associated carcinogenesis. J. Biol. Chem. 277 : 2687-2694, 2002.

Morimitsu Y., Nakagawa Y., Hayashi K., Fujii H., Kumagai T., Nakamura Y., Osawa T., Horio F., Itoh K., Iida K., Yamamoto M. and Uchida K.: A sulforaphane analogue that potently activates the Nrf2-dependent detoxification pathway. J. Biol. Chem. 277 : 3456-3463, 2002.

Feng Q.,Kumagai T., Torii Y., Nakamura Y., Osawa T. and Uchida K.: Anticarcinogenic antioxidants as inhibitors against intracellular oxidative stress. Free Radic. Res. 35 : 779-788, 2001.

Minekura H., Kumagai T.., Kawamoto Y., Nara F. and Uchida K.: 4-Hydroxy-2-nonenal is a powerful endogenous inhibitor of endothelial response. Biochem. Biophys. Res. Commun. 282 : 557-561, 2001.

Kondo M., Oya-Ito T., Kumagai T., Osawa T. and Uchida K.: Cyclopentenone prostaglandins as potential inducers of intracellular oxidative stress. J. Biol. Chem. 276 : 12076-12083, 2001.

Kumagai T., Kawamoto Y., Nakamura Y., Hatayama I., Satoh K., Osawa T. and Uchida K.: 4-Hydroxy-2-nonenal, the End Product of Lipid Peroxidation, Is a Specific Inducer of Cyclooxygenase-2 Gene Expression. Biochem. Biophys. Res. Commun. 273 : 437-441, 2000.

Kawamoto Y., Nakamura Y., Naito Y., Torii Y.,Kumagai T., Osawa T., Ohigashi H., Satoh K., Imagawa M. and Uchida K.: Cyclopentenone prostaglandins as potential inducers of phase II detoxification enzymes 15-deoxy-Delta(12,14)-prostaglandin J2-induced expression of glutathione S-transferases. J. Biol. Chem. 275 : 11291-11299, 2000.

Kumagai T., Yokoyama H., Goto A., Hirose J., Kadowaki T., Narita H. and Kitagawa Y.: Screening for Drosophila proteins with distinct expression patterns during development by use of monoclonal antibodies. Biosci. Biotechnol. Biochem. 64 : 24-8, 2000.

Suzuki H., Kumagai T., Sugiura T. and Goto A.: Increase in intracellular hydrogen peroxide and upregulation of a nuclear respiratory gene evoked by impairment of mitochondrial electron transfer in human cells. Biochem. Biophys. Res. Commun. 249 : 542-5, 1998.

Review

Imai H., Matsuoka M., Kumagai T., Sakamoto T., and Koumura T.: Lipid peroxidation-dependent cell death regulation by GPx4 and ferroptosis. Curr. Top. Microbiol. Immunol. 403 : 143-170, 2017.

Uchida K. and Kumagai T.: 4-hydroxy-2-nonenal as a COX-2 inducer. Mol.Aspects Med. 24 : 213-218, 2003.