| Staffs | mail (@pharm.kitasato-u.ac.jp) | ||
|---|---|---|---|
| Professor | Mitsuo Tanabe | tanabemi | |
| Lecturer | Yasuhito Naito | naitoy | |
| Lecturer | Takashi Iwai | iwait | |
| Assistant professor | Shun Watanabe | watanabes | |
| Assistant professor | Misa Oyama | oyamam | |
| Graduate students | ||||
|---|---|---|---|---|
| PhD course | Motoki Morita | |||
| Undergraduate students | ||||
|---|---|---|---|---|
| B６ | Taisei Kobayashi | Ruka Saitoh | Chinatsu Sakai | Ikumi Takagi |
| Tomohiro Takada | Fuhka Takenami | Shunki Tani | Yuhsuke Taima | |
| Ayako Fujino | Ayumi Hoshiyama | Ayano Miyake | Satomi Yoshikawa | |
| Risako Watanabe | Tokiteru Wada | |||
| B５ | Taisei Asano | Tomoka Ariga | Katsuya Ichida | Hayato Oosumi |
| Aya Katoh | Ayaka Kobayashi | Momoka Koyama | Karen Sannomiya | |
| Seira Nakamoto | Ai Higashiura | Aya Fukase | Yuuna Mase | |
| Kohei Mutoh | Nonoka Yasuo | |||
| B５ | Mitsuyo Uchida | Yuka Okabe | Ren Kurisu | Saki Kuriyama |
| Nanaka Shibata | Hikari Nagasawa | Ayano Nagase | Kano Hanya | |
| Chisa Bando | Nanako Hisano | Ikumi Hirano | Souma Matsumuro | |
| Moka Yoshida | ||||
| B３ | Haruto Yamamoto |
Acute pain is one of the symptoms associated with trauma and illness, and plays an important role as a warning signal. However, chronic pain such as neuropathic pain which persists after healing of the disease or tissue damage, or independently of them, no longer has physiological significance, and the pain itself is a detrimental disease to be treated.
In chronic pain conditions, enhanced efficacy of synaptic transmission in the dorsal horn of the spinal cord underlies central major aspects of hyperalgesia and tactile allodynia. Such increases in synaptic efficacy are ascribed to short- and long-term changes in the excitability of primary sensory afferent terminals and spinal dorsal horn neurons, including alterations in the function and/or expression of various receptors and ion channels which play a crucial role in the determination of membrane potential.
Furthermore, itch research focusing on the neural circuit of the dorsal horn of the spinal cord started worldwide in the 2010s, and we are also studying spinal itch mechanisms based on the knowledge gained from pain research.
Slice preparations of the spinal cord and brain maintaining neuronal networks are suitable for physiological and pharmacological studies of excitatory and inhibitory synaptic transmission.
We employ whole-cell patch-clamp recordings of excitatory synaptic currents mediated by Aδ-fibers and C-fibers from substantia gelatinosa neurons of spinal dorsal horn in slices prepared from adult mice. Patch-clamp is a powerful technique which allows us to study the pathophysiology of pain and itch and the mechanism of action of drugs at the functional level of synaptic transmission.
The Y- maze test is an experimental system that evaluates how much a mouse remembers the most recently searched passage when exploring the maze.
In collaboration with the Laboratory of Medicinal Chemistry, we are conducting research and development of effective compounds for the stress-induced impairment of working memory.
In the hippocampus, which is important for memory, excitatory synaptic transmission remains to be enhanced after a strong stimulus is temporarily applied (waveform: black → green). This is called synaptic plasticity and is considered as the molecular mechanism of memory.
We have shown that drugs previously reported to have antidepressant effects improve synaptic plasticity (red) impaired by intracerebral inflammation (green).
Morita M, Watanabe S, Nomura N, Takano-Matsuzaki K, Oyama M, Iwai T, Tanabe M
Sulfatide-selectin signaling in the spinal cord induces mechanical allodynia.
J Neurochem, 2022 Dec 17. doi: 10.1111/jnc.15743. Online ahead of print.
Oyama M, Watanabe S, Iwai T, Tanabe M
Distinct synaptic mechanisms underlying the analgesic effects of GABA transporter subtypes 1 and 3 inhibitors in the spinal dorsal horn.
Pain, 163:334-349 (2022).
Naoki Miyata, Mitsuo Tanabe, Eriko Uchida, Nana Kawasaki
Stems used in drug names: For the better understanding of pharmacological actions of drugs.
New stems defining nervous system agents:
-fenacin, -fensine, -isant, and -laner.
PHARM TECH JAPAN 38:1311-1316 (2022).(in Japanese)
Oyama M, Watanabe S, Iwai T, Tanabe M
Mirogabalin activates the descending noradrenergic system by binding to the α2δ-1 subunit of voltage-gated Ca2+ channels to generate analgesic effects.
J Pharmacol Sci, 146:33-39 (2021).
Naoki Miyata, Mitsuo Tanabe, Eriko Uchida, Nana Kawasaki
Stems used in drug names: For the better understanding of pharmacological actions of drugs.
Stems defining enzyme inhibitors:
-stat(-), -costat, -daxistat, -folastat, -glenastat.
PHARM TECH JAPAN 37:2677-2685 (2021).(in Japanese)
Eriko Uchida, Nana Kawasaki, Mitsuo Tanabe, Naoki Miyata
Stems used in drug names: For the better understanding of pharmacological actions of drugs.
Special edition: Therapeutic agents for COVID-19, Part 3: Biologicals and vaccines
PHARM TECH JAPAN 37:1569-1574 (2021).(in Japanese)
Naoki Miyata, Mitsuo Tanabe, Eriko Uchida, Nana Kawasaki
Stems used in drug names: For the better understanding of pharmacological actions of drugs.
Special edition: Therapeutic agents for COVID-19, Part 2
PHARM TECH JAPAN 37:1569-1574 (2021).(in Japanese)
Naoki Miyata, Masahiro Tohkin, Mitsuo Tanabe, Eriko Uchida, Nana Kawasaki
Stems used in drug names: For the better understanding of pharmacological actions of drugs.
Special edition: Therapeutic agents for COVID-19
PHARM TECH JAPAN 37:1371-1376 (2021).(in Japanese)
Naoki Miyata, Mitsuo Tanabe, Eriko Uchida, Nana Kawasaki
Stems used in drug names: For the better understanding of pharmacological actions of drugs.
A common stem defining enzyme inhibitors: -stat(-)
PHARM TECH JAPAN 37:787-793 (2021).(in Japanese)
Naoki Miyata, Mitsuo Tanabe, Eriko Uchida, Nana Kawasaki
Stems used in drug names: For the better understanding of pharmacological actions of drugs.
New stems defining specific enzyme inhibitors-2:
-parstat, polstat, -telstat, -tristat, -xestat, etc.
PHARM TECH JAPAN 37:109-116 (2021).(in Japanese)
Naoki Miyata, Mitsuo Tanabe, Eriko Uchida, Nana Kawasaki
Stems used in drug names: For the better understanding of pharmacological actions of drugs.
New stems defining specific enzyme inhibitors-1:
-becestat, -castat, -dustat, -elestat, -gacestat, etc.
PHARM TECH JAPAN 36:2427-2440 (2020).(in Japanese)
Naoki Miyata, Mitsuo Tanabe, Eriko Uchida, Nana Kawasaki
Stems used in drug names: For the better understanding of pharmacological actions of drugs.
New stems defining specific tyrosine kinase inhibitors:
-ertinib, -trectinib, -metinib, -xertinib, etc.
PHARM TECH JAPAN 36:1581-1591 (2020).(in Japanese)
Misa Oyama
リレーエッセイ「マークミスから始まった薬理学研究」.
Folia Pharmacologica Japonica 155:196 (2020).(in Japanese)
Takahashi J, Yamada D, Ueta Y, Iwai T, Koga E, Tanabe M, Oka JI, Saitoh A
Oxytocin reverses Aβ-induced impairment of hippocampal synaptic plasticity in mice.
Biochem Biophys Res Commun, 528:174-178 (2020).
Iwai T, Kikuchi A, Oyama M, Watanabe S, Tanabe M
Mirogabalin prevents repeated restraint stress-induced dysfunction in mice.
Behav Brain Res, 383:112506 (2020).
Morita M, Watanabe S, Oyama M, Iwai T, Tanabe M
Glycosphingolipid biosynthesis pathway in the spinal cord and dorsal root ganglia during inflammatory pain: early and late changes in expression patterns of glycosyltransferase genes.
Neuroscience, 428:217-227 (2020).
Naoki Miyata, Mitsuo Tanabe, Eriko Uchida, Nana Kawasaki
Stems used in drug names: For the better understanding of pharmacological actions of drugs, continued (Nr. 18).
PHARM TECH JAPAN 35:2645-2652 (2019).(in Japanese)
Nana Kawasaki, Eriko Uchida, Mitsuo Tanabe, Naoki Miyata
Stems used in drug names: For the better understanding of pharmacological actions of drugs, continued (Nr. 17).
PHARM TECH JAPAN 35:2351-2359 (2019).(in Japanese)
Naoki Miyata, Mitsuo Tanabe
ステム手帖-6.
MEDCHEM NEWS 29:137 (2019).(in Japanese)
Naoki Miyata, Mitsuo Tanabe, Eriko Uchida, Nana Kawasaki
Stems used in drug names: For the better understanding of pharmacological actions of drugs, continued (Nr. 16).
PHARM TECH JAPAN 35:2105-2115 (2019).(in Japanese)
Naoki Miyata, Mitsuo Tanabe, Eriko Uchida, Nana Kawasaki
Stems used in drug names: For the better understanding of pharmacological actions of drugs, continued (Nr. 15).
PHARM TECH JAPAN 35:1771-1778 (2019).(in Japanese)
Nana Kawasaki, Eriko Uchida, Yoji Sato, Mitsuo Tanabe, Naoki Miyata
Stems used in drug names: For the better understanding of pharmacological actions of drugs, continued (Nr. 14).
PHARM TECH JAPAN 35:1559-1567 (2019).(in Japanese)
Naoki Miyata, Mitsuo Tanabe, Eriko Uchida, Nana Kawasaki
Stems used in drug names: For the better understanding of pharmacological actions of drugs, continued (Nr. 13).
PHARM TECH JAPAN 35:1147-1156 (2019).(in Japanese)
Eriko Uchida, Nana Kawasaki, Naoki Miyata, Mitsuo Tanabe
Stems used in drug names: For the better understanding of pharmacological actions of drugs, continued (Nr. 12).
PHARM TECH JAPAN 35:955-964 (2019).(in Japanese)
Hirayama s, Iwai T, Higashi E, Nakamura M, Iwamatsu C, Itoh K, Nemoto T, Tanabe M, Fujii H
Discovery of δ Opioid Receptor Full Inverse Agonists and Their Effects on Restraint Stress-Induced Cognitive Impairment in Mice.
NACS Chem Neurosci, 10:2237-2242 (2019).
Ikeda-Matsuo Y, Miyata H, Mizoguchi T, Ohama E, Naito Y, Uematsu S, Akira S, Sasaki Y, Tanabe M
Microsomal prostaglandin E synthase-1 is a critical factor in dopaminergic neurodegeneration in Parkinson's disease.
Neurobiol Dis, 124:81-92 (2019).
田辺光男
パートナー薬理学 改定第３版（共著） 南江堂 (2019)，第4章 中枢神経系に作用する薬物，
| 1 中枢神経系の形態と機能，91-94. |
| 4 鎮痛薬，107-121. |
| 5 抗てんかん薬，122-127. |
| 7 中枢性筋弛緩薬，143-146. |
| 8 好パーキンソン病薬，146-151. |
Naoki Miyata, Mitsuo Tanabe, Eriko Uchida, Nana Kawasaki
Stems used in drug names: For the better understanding of pharmacological actions of drugs, continued (Nr. 11).
PHARM TECH JAPAN 35:653-658 (2019).(in Japanese)
Naoki Miyata, Mitsuo Tanabe
ステム手帖-4.
MEDCHEM NEWS 29:21 (2019).(in Japanese)
Eriko Uchida, Nana Kawasaki, Mitsuo Tanabe, Naoki Miyata
Stems used in drug names: For the better understanding of pharmacological actions of drugs, continued (Nr. 10).
PHARM TECH JAPAN 35:385-392 (2019).(in Japanese)
Naoki Miyata, Mitsuo Tanabe, Eriko Uchida, Nana Kawasaki
Stems used in drug names: For the better understanding of pharmacological actions of drugs, continued (Nr. 9).
PHARM TECH JAPAN 35:151-159 (2019).(in Japanese)
Nana Kawasaki, Eriko Uchida, Mitsuo Tanabe, Naoki Miyata
Stems used in drug names: For the better understanding of pharmacological actions of drugs, continued (Nr. 8).
PHARM TECH JAPAN 34:3227-3235 (2018).(in Japanese)
Mitsuo Tanabe, Nana Kawasaki, Eriko Uchida, Naoki Miyata
Stems used in drug names: For the better understanding of pharmacological actions of drugs, continued (Nr. 7).
PHARM TECH JAPAN 34:3031-3039 (2018).(in Japanese)
Nana Kawasaki, Eriko Uchida, Mitsuo Tanabe, Naoki Miyata
Stems used in drug names: For the better understanding of pharmacological actions of drugs, continued (Nr. 6).
PHARM TECH JAPAN 34:2797-2804 (2018).(in Japanese)
Naoki Miyata, Mitsuo Tanabe, Eriko Uchida, Nana Kawasaki
Stems used in drug names: For the better understanding of pharmacological actions of drugs, continued (Nr. 5).
PHARM TECH JAPAN 34:2473-2478 (2018).(in Japanese)
Naoki Miyata, Mitsuo Tanabe
ステム手帖-2.
MEDCHEM NEWS 28:143 (2018).(in Japanese)
Naoki Miyata, Mitsuo Tanabe, Nana Kawasaki, Eriko Uchida
Stems used in drug names: For the better understanding of pharmacological actions of drugs, continued (Nr. 4).
PHARM TECH JAPAN 34:2211-2217 (2018).(in Japanese)
Naoki Miyata, Mitsuo Tanabe, Nana Kawasaki
Stems used in drug names: For the better understanding of pharmacological actions of drugs, continued (Nr. 3).
PHARM TECH JAPAN 34:1831-1840 (2018).(in Japanese)
Nana Kawasaki, Mitsuo Tanabe, Naoki Miyata
Stems used in drug names: For the better understanding of pharmacological actions of drugs, continued (Nr. 2).
PHARM TECH JAPAN 34:1487-1493 (2018).(in Japanese)
Naoki Miyata, Mitsuo Tanabe, Nana Kawasaki
Stems used in drug names: For the better understanding of pharmacological actions of drugs, continued (Nr. 1).
PHARM TECH JAPAN 34:1273-1278 (2018).(in Japanese)
Shun Watanabe, Mitsuo Tanabe
Review Article: Sialic acid-containing glycisphingolipids: functional roles of gangliosides in pain signaling.
PAIN RESEARCH 33:32-39 (2018).(in Japanese)
Oyama M, Kuraoka S, Watanabe S, Iwai T, Tanabe M
Electrophysiological evidence of increased glycine receptor-mediated phasic and tonic inhibition by blockade of glycine transporters in spinal superficial dorsal horn neurons of adult mice.
J Pharmacol Sci, 133:162-167 (2017).
Watanabe S, Iwai T, Tanabe M
Intraplantar injection of sialidase reduces mechanical allodynia during inflammatory pain.
J Pharmacol Sci, 133:49-52 (2017).
Iwai Takahashi
トピックス「慢性痛に関わる免疫細胞の性差」.
ファルマシア 152:179 (2016). (in Japanese)
Iwai T, Jin K, Ohnuki T, Sasaki-Hamada S, Nakamura M, Saitoh A, Sugiyama A, Ikeda M, Tanabe M, Oka JI
Glucagon-like peptide-2-induced memory improvement and anxiolytic effects in mice.
Neuropeptides, 49:7-14 (2015).
Shun Watanabe, Mitsuo Tanabe
キーワード解説「ガングリオシドの機能と疼痛」.
Folia Pharmacologica Japonica 145:216-218 (2015).(in Japanese)
Yuri Matsuo
神経ネットワークによる成体神経新生の制御.
Folia Pharmacologica Japonica 145:43 (2015).(in Japanese)
Tomoyose O, Kodama D, Ono H, Tanabe M
Presynaptic inhibitory effects of fluvoxamine, a selective serotonin reuptake inhibitor, on nociceptive excitatory synaptic transmission in spinal superficial dorsal horn neurons of adult mice.
J Pharmacol Sci, 126:136-145 (2014).
Iwai T, Sawabe T, Tanimitsu K, Suzuki M, Sasaki-Hamada S, Oka J
Glucagon-like peptide-1 protects synaptic and learning functions from neuroinflammation in rodents.
J Neurosci Res, 92:446-454 (2014).
Yuri Matsuo
特集 脳内炎症の制御を基盤とした脳血管疾患の新規治療戦略抗プロスタグランジンE2薬の脳梗塞治療薬としての可能性（特集 脳内炎症の制御を基盤とした脳血管疾患の新規治療戦略2）.
Folia Pharmacologica Japonica 144:110-114 (2014).(in Japanese)
Mitsuo Tanabe
脊髄視床路（新・旧）.
日本医師会雑誌（痛みのマネジメントupdate 基礎知識から緩和ケアまで） 143特別号(1):S40-S41 (2014).(in Japanese)
Mitsuo Tanabe
Electrophysiological evaluation of pathophysiological and pharmacological characterization of chronic pain.
YAKUGAKU ZASSHI 134(3):405-412 (2014).(abstract in English)
Hashimoto T, Yamada M, Iwai T, Saitoh A, Hashimoto E, Ukai W, Saito T, Yamada M
Plasticity-related gene 1 is important for survival of neurons derived from rat neural stem cells.
J Neurosci Res, 91:1402-1407 (2013).
Iwai T, Kaneko M, Sasaki-Hamada S, Oka J
Characterization of the hypotensive effects of glucagon-like peptide-2 in anesthetized rats.
Neurosci Lett, 550:104-108 (2013).
Iwai T, Ohnuki T, Sasaki-Hamada S, Saitoh A, Sugiyama A, Oka J
Glucagon-like peptide-2 but not imipramine exhibits antidepressant-like effects in ACTH-treated mice.
Behav Brain Res, 243:153-157 (2013).
Kobayashi K, Iwai T, Sasaki-Hamada S, Kamanaka G, Oka J
Exendin (5-39), an antagonist of GLP-1 receptor, modulates synaptic transmission via glutamate uptake in the dentate gyrus.
Brain Res, 1505:1-10 (2013).
Yuri Matsuo
The role of prostaglandin E2 in stroke-reperfusion injury.
YAKUGAKU ZASSHI 133(9):947-954 (2013).(abstract in English)
Mitsuo Tanabe
医薬品の名前 ステムを知ればクスリがわかる（共著）（宮田直樹/編著） じほう (2013年2月).
Naoki Miyata, Mitsuo Tanabe
一般名がわかるステムの知識 ①化学薬品.
日本薬剤師会雑誌 65(1):19-25 (2013).(in Japanese)
Ohnami S, Kato A, Ogawa K, Shinohara S, Ono H, Tanabe M
Effect of milnacipran, a serotonin and noradrenaline reuptake inhibitor, on C-fiber-evoked field potentials in spinal long-term potentiation and neuropathic pain.
Br J Pharmacol, 167:537-547 (2012).
Young SZ, Taylor MM, Wu S, Ikeda-Matsuo Y, Kubera C, Bordey A
NKCC1 Knockdown Decreases Neuron Production through GABAA-Regulated Neural
Progenitor Proliferation and Delays Dendrite Development.
J Neurosci, 32:13630-13638 (2012).
Yamamoto S, Tanabe M, Ono H
N- and L-type voltage-dependent Ca2+ channels contribute to the generation of
after-discharges in the spinal ventral root after cessation of noxious mechanical
stimulation.
J Pharmacol Sci, 119:82-90 (2012).
Taniguchi S, Kimura T, Umeki T, Kimura Y, Kimura H, Ishii I, Itoh N, Naito Y,
Yamamoto H, Niki I
Protein phosphorylation involved in the gene expression of the hydrogen sulphide
producing enzyme cystathionine γ-lyase in the pancreatic β-cell.
Mol Cell Endocrinol, 350:31-38 (2012).
Tanabe A, Shiraishi M, Negishi M, Saito N, Tanabe M, Sasaki Y
MARCKS dephosphorylation is involved in bradykinin-induced neurite outgrowth in neuroblastoma SH-SY5Y cells.
J Cell Physiol, 227:618-629 (2012).
田辺光男，高須景子，大波壮一郎，小野秀樹
下行性制御機構：下行性制御機構を標的とした薬物（ガバペンチン,プレガバリン,ミルナシプランなど）.
Bone Joint Nerve（特集 慢性疼痛のup to date）2(2):239-247 (2012).
田辺光男
カッツング薬理学エッセンシャル（共訳） 丸善 (2012)，VI 血液疾患，炎症，痛風の治療薬，
| 33 貧血治療薬と造血性増殖因子，295-303. |
| 34 血液凝固異常治療薬，304-315. |
| 35 高脂血症治療薬，316-324. |
| 36 非ステロイド性抗炎症薬，アセトアミノフェン，抗リウマチ薬，痛風治療薬，325-335. |
田辺光男
最新薬理学（共著） 廣川書店 (2012)，第4章 中枢神経薬理，
| 4-8 催眠薬・抗不安薬（鎮静薬），212-232. |
| 4-9 全身麻酔薬，232-241. |
| 4-10 麻薬性鎮痛薬，241-253. |
| 4-11 薬物の耐性と依存性，254-256. |
Ikeda-Matsuo Y, Tanji H, Narumiya S, Sasaki Y
Inhibition of prostaglandin E2 EP3 receptors improves stroke injury via anti-inflammatory and anti-apoptotic mechanisms.
J Neuroimmunol, 238:34-43 (2011)
Takata T, Kimura J, Tsuchiya Y, Naito Y, Watanabe Y
Calcium/calmodulin-dependent protein kinases as potential targets of nitric
oxide.
Nitric Oxide, 25:145-152 (2011).
Kodama D, Ono H, Tanabe M
Increased hippocampal glycine uptake and cognitive dysfunction after peripheral nerve injury.
Pain 152:809-817 (2011).
Ohnami S, Tanabe M, Shinohara S, Takasu K, Kato A, Ono H
Role of voltage-dependent calcium channel subtypes in spinal long-term potentiation of C-fiber-evoked field potentials.
Pain 152:623-631 (2011).
田辺光男
ガバペンチンによる鎮痛効果.
ペインクリニック（特集 臨床を裏づける神経障害性疼痛の本態）32(10):1472-1480 (2011).
Takasu K, Ono H, Tanabe M
Spinal hyperpolarization-activated cyclic nucleotide-gated cation channels at primary afferent terminals contribute to chronic pain.
Pain 151:87-96 (2010).
Tanabe M, Nitta A, Ono H
Neuroprotection via strychnine-sensitive glycine receptors during post-ischemic recovery of excitatory synaptic transmission in the hippocampus.
J Pharmacol Sci 113:378-386 (2010).
Ikeda-Matsuo Y, Tanji H, Ota A, Hirayama Y, Uematsu S, Akira S, Sasaki Y
Microsomal prostaglandin E synthase-1 contributes to ischaemic excitotoxicity
through prostaglandin E2 EP3 receptors.
Br J Pharmacol 160:847-859 (2010).
Ikeda-Matsuo Y, Hirayama Y, Ota A, Uematsu S, Akira S, Sasaki Y
Microsomal prostaglandin E synthase-1 and cyclooxygenase-2 are both required for
ischaemic excitotoxicity.
Br J Pharmacol 159:1174-1186 (2010).
Kambe T, Song T, Takata T, Hatano N, Miyamoto Y, Nozaki N, Naito Y, Tokumitsu H,
Watanabe Y
Inactivation of Ca2+/calmodulin-dependent protein kinase I by S-glutathionylation
of the active-site cysteine residue.
FEBS Lett 584:2478-2484 (2010).
Ikeda-Matsuo Y
Microsomal prostaglandin E synthase-1 is involved in the brain ischemic injury.
Inflammation and Regeneration
30:26-33 (2010).
田辺光男
グリシントランスポーター（GlyT）.
生体の科学（増大特集 シナプスをめぐるシグナリング）61(5):408-409 (2010).
佐々木泰治，松尾由理
病態生理からアプローチした薬物療法：炎症性疾患の病態生理.
保険薬剤師さんのための実用情報誌 ファーマシストぷらす 10:4-9 (2010).
Takasu K, Kinoshita Y, Ono H, Tanabe M
Protein kinase A-dependence of the supraspinally mediated analgesic effects of gabapentin on thermal and mechanical hypersensitivity.
J Pharmacol Sci 110:223-226 (2009).
Tanabe M, Ono K, Honda M, Ono H
Gabapentin and pregabalin ameliorate mechanical hypersensitivity developing after spinal cord injury in mice.
Eur J Pharmacol 609:65-68 (2009).
Tanabe M, Nakano T, Honda M, Ono H
Glycine transporter blockade ameliorates motor ataxia in a mouse model of spinocerebellar atrophy.
J Pharmacol Sci 109:444-448 (2009).
Tanabe M, Nagatani Y, Saitoh K, Takasu K, Ono H
Pharmacological assessments of nitric oxide synthase isoforms and downstream diversity of NO signaling in the maintenance of thermal and mechanical hypersensitivity after peripheral nerve injury in mice.
Neuropharmacology 56:702-708 (2009).
田辺光男, 高須景子, 小野秀樹
総説「ガバペンチンの上位中枢を介する神経因性疼痛緩解作用」.
日本薬理学雑誌 134:299-303 (2009).
田辺光男
薬に強くなる12 抗パーキンソン病薬.
看護技術 55(14):1547-1551 (2009).
田辺光男
σ1受容体と海馬スライスの過分極誘発カチオン電流.
生体の科学（増大特集 伝達物質と受容体）60(5):466-467 (2009).
Tanabe M, Takasu K, Takeuchi Y, Ono H
Mini-Review Pain relief by gabapentin and pregabalin via supraspinal mechanisms after peripheral nerve injury.
J Neurosci Res 86:3258-3264 (2008).
Tanabe M, Hashimoto M, Ono H
I1-imidazoline receptor-mediated reduction of muscle rigidity in the reserpine-treated murine model of Parkinson disease.
Eur J Pharmacol 589:102-105 (2008).
Tanabe M, Murakami T, Ono H
Zonisamide suppresses pain symptoms of formalin-induced inflammatory and streptozotocin-induced diabetic neuropathic pain.
J Pharmacol Sci 107:213-220 (2008).
Tanabe M, Takasu K, Yamaguchi S, Kodama D, Ono H
Glycine transporter inhibitors as a potential therapeutic strategy for chronic pain with memory impairment.
Anesthesiology 108:929-937 (2008).
Takasu K, Ono H, Tanabe M
Gabapentin produces PKA-dependent presynaptic inhibition of GABAergic synaptic transmission in locus coeruleus neurons following partial nerve injury in mice.
J Neurochem 105:933-942 (2008).
Ono H, Nagano Y, Matsunami N, Sugiyama S, Yamamoto S, Tanabe M
Oseltamivir, an anti-influenza virus drug, produces hypothermia in mice: Comparison among oseltamivir, zanamivir and diclofenac.
Biol Pharm Bull 31:638-642 (2008).
田辺光男
キーワード解説「イミダゾリン受容体」.
ú日本薬理学雑誌 131:478-480 (2008).
Takeuchi Y, Takasu K, Ono H, Tanabe M
Pregabalin, S-(+)-3-isobutylgaba, activates the descending noradrenergic system to alleviate neuropathic pain in the mouse partial sciatic nerve ligation model.
Neuropharmacology 53:842-853 (2007).
Kodama D, Ono H, Tanabe M
Altered hippocampal long-term potentiation after peripheral nerve injury in mice.
Eur J Pharmacol 574:127-132 (2007).
Tanabe M
Inhibition of hyperpolarization-activated cation currents by phencyclidine and some sigma ligands in rat CA1 pyramidal neurons in vitro.
Neuropahrmacology 53:406-414 (2007).
Tanabe M, Takeuchi Y, Ono H
The supraspinally mediated analgesic effects of zonisamide in mice after peripheral nerve injury are independent of the descending monoaminergic system.
J Pharmacol Sci 104:335-340 (2007).
Tanabe M, Tokuda Y, Takasu K, Ono K, Honda M, Ono H
The synthetic TRH analogue taltirelin produces modality specific antinociception via distinct monoaminergic systems.
Br J Pharmacol 150:403-414 (2007).
Takeuchi Y, Takasu K, Honda M, Ono H, Tanabe M
Neurochemical evidence that supraspinally administered gabapentin activates the descending noradrenergic system after peripheral nerve injury.
Eur J Pharmacol 556:69-74 (2007).
田辺光男
薬学テキストシリーズ 薬理学－基礎から薬物治療学へ－（共著）朝倉書店, 195-206 (2007).
Tanabe M, Umeda M, Honda M, Ono H
Phenytoin and carbamazepine delay the initial depression of the population spike upon exposure to in vitro ischemia and promote its post-ischemic functional recovery in rat hippocampal slices.
Eur J Pharmacol 553:104-108 (2006).
Tanabe M, Murakami H, Honda M, Ono H
Gabapentin depresses C-fiber-evoked field potentials in rat spinal dorsal horn
only after induction of long-term potentiation.
Exp Neurol 202:280-286 (2006).
Honda M, Tanabe M, Ono H
Spinal cord injury-specific depression of monosynaptic reflex transmission by L-5-hydroxytryptophan results from loss of the 5-HT uptake system and not 5-HT receptor supersensitivity.
Exp Neurol 202:258-261 (2006).
Honda M, Uchida K, Tanabe M, Ono H
Fluvoxamine, a selective serotonin upteke inhibitor, exerts its antiallodyniceffects on neuropathic pain in mice via 5-HT2A/2C receptors.
Neuropharmacology 51:866-872 (2006).
Takasu K, Honda M, Ono H, Tanabe M
Spinal α2-adrenergic and muscarinic receptors and the NO release cascade mediate supraspinally produced effectiveness of gabapentin at decreasing mechanical hypersensitivity in mice after partical nerve injury.
Br J Pharmacol 148:233-244 (2006).
Yamamoto S, Honda M, Tanabe M, Ono H
Spinal ventral root after-discharges as a pain index: involvement of NK-1 and NMDA receptors.
Brain Res 1082:115-123 (2006).
Tanabe M, Kino Y, Honda M, Ono H
Presynaptic I1-imidazoline receptors reduce GABAergic synaptic transmission in striatal medium spiny neurons.
J Neurosci 26:1795-1802 (2006).
田辺光男, 小野秀樹
キーワード解説「神経因性疼痛」.
日本薬理学雑誌 128:346-348 (2006).
Tanabe M, Shimizu S, Takabayashi K, Honda M, Ono H
Functional alteration of inhibitory influences on spinal motor output in painful diabetic neuropathy in rats.
Neurosci Lett 389:152-156 (2005).
Nakamura T, Honda M, Kimura S, Tanabe M, Oda S, Ono H
Taltirelin improves motor ataxia independently of monoamine levels in rolling mouse Nagoya, a model of spinocerebellar atrophy.
Biol Pharm Bull 28:2244-2247 (2005).
Kino Y, Tanabe M, Honda M, Ono H
Involvement of supraspinal imidazoline receptors and descending monoaminergic pathways in tizanidine-induced inhibition of rat spinal reflexes.
J Pharmacol Sci 99:52-60 (2005).
Tanabe M, Sakaue A, Takasu K, Honda M, Ono H
Centrally mediated antihyperalgesic and antiallodynic effects of zonisamide following partial nerve injury in the mouse.
Naunyn-Schmiedeberg's Arch Pharmacol 372:107-114 (2005).
Tanabe M, Takasu K, Kasuya N, Shimizu S, Honda M, Ono H
Role of descending noradrenergic system and spinal α2-adrenergic receptors in the effects of gabapentin on thermal and mechanical nociception after partial nerve injury in the mouse.
Br J Pharmacol 144:703-714 (2005).
Kimura S, Tanabe M, Honda M, Ono H
Enhanced wind-up of the C-fiber-mediated nociceptive flexor reflex movement following painful diabetic neuropathy in mice.
J Pharmacol Sci 97:195-202 (2005).
Shimizu S, Honda M, Tanabe M, Ono H
GABAB receptors do not mediate the inhibitory actions of gabapentin on the spinal reflex in rats.
J Pharmacol Sci 96:444-449 (2004).
Honda M, Imaida K, Tanabe M, Ono H
Endogenously released 5-hydroxytryptamine depresses the spinal monosynaptic reflex via 5-HT1D receptors.
Eur J Pharmacol 503:55-61 (2004).
Sakaue A, Honda M, Tanabe M, Ono H
Antinociceptive effects of sodium channel-blocking agents on acute pain in mice.
J Pharmacol Sci 95:181-188 (2004).
Kimura S, Honda M, Tanabe M, Ono H
Noxious stimuli evokea biphasic flexor reflex composed of Aδ-fiber-mediated short-latency and C-fiber-mediated long-latency withdrawal movements in mice.
J Pharmacol Sci 95:94-100 (2004). Erratum.]
Shimizu S, Honda M, Tanabe M, Oka J, Ono H
Endogenous GABA does not mediate the inhibitory effects of gabapentin on spinal reflexes in rats.
J Pharmacol Sci 94:137-143 (2004).
Honda M, Tanabe M, Ono H
Serotonergic depression of spinal monosynaptic transmission is mediated by 5-HT1B receptors.
Eur J Pharmacol 482:155-161 (2003).
Inoue R, Tanabe M, Kono K, Maruyama K, Ikemoto T, Endo M
Ca2+-releasing effect of cerivastatin on the sarcoplasmic reticulum of mouse and rat skeletal muscle fibers.
J Pharmacol Sci 93:279-288 (2003).