1. 189. Uenaka M, Uyeda A, Nakahara T, Muramatsu R. LPA2 promotes neuronal differentiation and neurite formation in neocortical development. Biochem Biophys Res Commun. 2022 Apr 2;598:89-94. doi: 10.1016/j.bbrc.2022.01.109.

  2. 188. Kashihara T, Mukai R, Oka SI, Zhai P, Nakada Y, Yang Z, Mizushima W, Nakahara T, Warren JS, Abdellatif M, Sadoshima J. YAP mediates compensatory cardiac hypertrophy through aerobic glycolysis in response to pressure overload. J Clin Invest. 2022 Mar 15;132(6):e150595. doi: 10.1172/JCI150595.

  3. 187. Mori A, Sumida D, Kondo R, Nakano A, Arima S, Asano D, Morita A, Sakamoto K, Nagamitsu T, Nakahara T. Impairment of endothelium-dependent vasodilator function of retinal blood vessels in adult rats with a history of retinopathy of prematurity. J Pharmacol Sci. 2021 Aug;146(4):233-243. doi: 10.1016/j.jphs.2021.04.008.

  4. 186. Watanabe K, Asano D, Ushikubo H, Morita A, Mori A, Sakamoto K, Ishii K, Nakahara T. Metformin Protects against NMDA-Induced Retinal Injury through the MEK/ERK Signaling Pathway in Rats. Int J Mol Sci. 2021 Apr 23;22(9):4439. doi: 10.3390/ijms22094439.

  5. 185. Mori A, Takei T, Suzuki N, Sakamoto K, Morita M, Nakagawa S, Nakahara T, Ishii K. L-Citrulline ameliorates the attenuation of acetylcholine-induced vasodilation of retinal arterioles in diabetic rats. Heliyon. 2021 Mar 21;7(3):e06532. doi: 10.1016/j.heliyon.2021.e06532.

  6. 184. Mori A, Yano E, Sakamoto K, Ishii K, Nakahara T. Role of Epoxyeicosatrienoic Acids in Acetylcholine-Induced Dilation of Rat Retinal Arterioles in Vivo. Biol Pharm Bull. 2021;44(1):82-87. doi: 10.1248/bpb.b20-00635.

  7. 183. Morita A, Yoshizumi M, Arima S, Mori A, Sakamoto K, Nagamitsu T, Nakahara T. Pharmacological depletion of retinal neurons prevents vertical angiogenic sprouting without affecting the superficial vascular plexus. Dev Dyn. 2021 Apr;250(4):497-512. doi: 10.1002/dvdy.263.

  8. 182. Morita A, Goko T, Matsumura M, Asaso D, Arima S, Mori A, Sakamoto K, Nagamitsu T, Nakahara T. The process of revascularization in the neonatal mouse retina following short-term blockade of vascular endothelial growth factor receptors. Cell Tissue Res. 2020 Dec;382(3):529-549. doi: 10.1007/s00441-020-03276-9.

  9. 181.Mori A, Namekawa R, Sakamoto K, Ishii K, Nakahara T. 4-Aminopyridine, a Voltage-Gated K+ Channel Inhibitor, Attenuates Nitric Oxide-Mediated Vasodilation of Retinal Arterioles in Rats. Biol Pharm Bull. 2020;43(7):1123-1127. doi: 10.1248/bpb.b20-00220.

  10. 180. Mori A, Taniai A, Hasegawa M, Sakamoto K, Nakahara T. Involvement of Gi protein-dependent BKCa channel activation in β2-adrenoceptor-mediated dilation of retinal arterioles in rats. Naunyn Schmiedebergs Arch Pharmacol. 2020 Nov;393(11):2043-2052. doi: 10.1007/s00210-020-01895-1.

  11. 179. Kondo R, Nakano A, Asano D, Morita A, Arima S, Mori A, Sakamoto K, Nagamitsu T, Nakahara T. Abnormal Vascular Phenotypes Associated with the Timing of Interruption of Retinal Vascular Development in Rats. Biol Pharm Bull. 2020;43(5):859-863. doi: 10.1248/bpb.b19-01065.

  12. 178. Sakamoto K, Asano D, Morita A, Mori A, Nakahara T. Expression changes in microRNA in the retina of retinal degenerative diseases. Nihon Yakurigaku Zasshi. 2020;155(2):81-86. doi: 10.1254/fpj.19121.

  13. 177. Matsumoto K, Deguchi A, Motoyoshi A, Morita A, Maebashi U, Nakamoto T, Kawanishi S, Sueyoshi M, Nishimura K, Takata K, Tominaga M, Nakahara T, Kato S. Role of transient receptor potential vanilloid subtype 4 in the regulation of azoymethane/dextran sulphate sodium-induced colitis-associated cancer in mice. Eur J Pharmacol. 2020 Jan 15;867:172853. doi: 10.1016/j.ejphar.2019.172853.

  14. 176. Nakano A, Kondo R, Kaneko Y, Arima S, Asano D, Morita A, Sakamoto K, Nagamitsu T, Nakahara T. Changes in components of the neurovascular unit in the retina in a rat model of retinopathy of prematurity. Cell Tissue Res. 2020 Mar;379(3):473-486. doi: 10.1007/s00441-019-03112-9.

  15. 175. Asano D, Hokazono M, Hirano S, Morita A, Nakahara T. Cellular Mechanisms of Angiogenesis in Neonatal Rat Models of Retinal Neurodegeneration. Int J Mol Sci. 2019 Sep 25;20(19):4759. doi: 10.3390/ijms20194759.

  16. 174. Mori A, Takeda K, Sakamoto K, Nakahara T. Activation of transient receptor potential vanilloid 4 channels dilates rat retinal arterioles through nitric oxide- and BKCa channel-dependent mechanisms in vivo. Naunyn Schmiedebergs Arch Pharmacol. 2020 Jan;393(1):35-41. doi: 10.1007/s00210-019-01707-1.

  17. 173. Nakano A, Mori A, Arima S, Asano D, Morita A, Sakamoto K, Nagamitsu T, Nakahara T. Attenuation of Retinal Endothelial Vasodilator Function in a Rat Model of Retinopathy of Prematurity. Curr Eye Res. 2019 Dec;44(12):1360-1368. doi: 10.1080/02713683.2019.1641825.

  18. 172. Someya E, Akagawa M, Mori A, Morita A, Yui N, Asano D, Sakamoto K, Nakahara T. Role of Neuron⁻Glia Signaling in Regulation of Retinal Vascular Tone in Rats. Int J Mol Sci. 2019 Apr 20;20(8):1952. doi: 10.3390/ijms20081952.

  19. 171. Asano D, Morita A, Mori A, Sakamoto K, Ishii K, Nakahara T. Involvement of matrix metalloproteinases in capillary degeneration following NMDA-induced neurotoxicity in the neonatal rat retina. Exp Eye Res. 2019 May;182:101-108. doi: 10.1016/j.exer.2019.03.005.

  20. 170. Hayashi H, Mamun AA, Takeyama M, Yamamura A, Zako M, Yagasaki R, Nakahara T, Kamei M, Sato M. Activator of G-protein signaling 8 is involved in VEGF-induced choroidal neovascularization. Sci Rep. 2019 Feb 7;9(1):1560. doi: 10.1038/s41598-018-38067-4.

  21. 169. Higashi K, Mori A, Sakamoto K, Ishii K, Nakahara T. Probucol slows the progression of cataracts in streptozotocin-induced hyperglycemic rats. Pharmacology. 2019; 103(3-4): 212-219. doi: 10.1159/000496055.

  22. 168. Iizuka N, Morita A, Kawano C, Mori A, Sakamoto K, Kuroyama M, Ishii K, Nakahara T. Anti-angiogenic effects of valproic acid in a mouse model of oxygen-induced retinopathy. J Pharmacol Sci. 2018 Nov;138(3):203-208. doi: 10.1016/j.jphs.2018.10.004.

  23. 167. Higashi Y, Higashi K, Mori A, Sakamoto K, Ishii K, Nakahara T. Anti-cataract Effect of Resveratrol in High-Glucose-Treated Streptozotocin-Induced Diabetic Rats. Biol Pharm Bull. 2018;41(10):1586-1592. doi: 10.1248/bpb.b18-00328.

  24. 166. Sakamoto K, Mori A, Ishii K, Nakahara T. [Selective neuronal cell death in retinal degenerative diseases]. Nihon Yakurigaku Zasshi. 2018;152(2):58-63. doi: 10.1254/fpj.152.58. Japanese.

  25. 165. Sakamoto K, Inukai M, Mori A, Nakahara T. Brilliant Blue G protects against photoreceptor injury in a murine endotoxin-induced uveitis model. Exp Eye Res. 2018 Dec;177: 45-49. doi: 10.1016/j.exer.2018.07.028.

  26. 164. Sakamoto K, Suzuki T, Takahashi K, Koguchi T, Hirayama T, Mori A, Nakahara T, Nagasawa H, Ishii K. Iron-chelating agents attenuate NMDA-Induced neuronal injury via reduction of oxidative stress in the rat retina. Exp Eye Res. 2018 Jun; 171:30-36. doi: 10.1016/j.exer.2018.03.008.

  27. 163. Morita A, Sawada S, Mori A, Arima S, Sakamoto K, Nagamitsu T, Nakahara T. Establishment of an abnormal vascular patterning model in the mouse retina. J Pharmacol Sci. 2018 Apr;136(4):177-188. doi: 10.1016/j.jphs.2018.03.002.

  28. 162. Sakamoto K, Suzuki T, Takahashi K, Koguchi T, Hirayama T, Mori A, Nakahara T, Nagasawa H, Ishii K. Iron-chelating agents attenuate NMDA-Induced neuronal injury via reduction of oxidative stress in the rat retina. Exp Eye Res. 171: 30-36, 2018. doi: 10.1016/j.exer.2018.03.008.

  29. 161. Sone K, Mori A, Sakamoto K, Nakahara T. GYY4137, an Extended-Release Hydrogen Sulfide Donor, Reduces NMDA-Induced Neuronal Injury in the Murine Retina. Biol Pharm Bull. 41: 657-660, 2018. doi: 10.1248/bpb.b17-01032.

  30. 160. Akagawa M, Mori A, Sakamoto K, Nakahara T. Methylglyoxal Impairs β2-Adrenoceptor-Mediated Vasodilatory Mechanisms in Rat Retinal Arterioles. Biol Pharm Bull. 41 :272-276, 2018. doi: 10.1248/bpb.b17-00861.

  31. 159. Nakano A, Asano D, Kondo R, Mori A, Arima S, Ushikubo H, Sakamoto K, Nagamitsu T, Ishii K, Nakahara T. Retinal neuronal cell loss prevents abnormal retinal vascular growth in a rat model of retinopathy of prematurity. Exp Eye Res. 168: 115-127, 2018. doi: 10.1016/j.exer.2017.12.007.

  32. 158. Morita A, Mori A, Arima S, Sakamoto K, Nagamitsu T, Ishii K, Nakahara T. Transient phenotypic changes in endothelial cells and pericytes in neonatal mouse retina following short-term blockade of vascular endothelial growth factor receptors. Dev Dyn. 2017 Dec 16. doi: 10.1002/dvdy.24614. [Epub ahead of print]

  33. 157. Someya E, Mori A, Asano D, Morita A, Sakamoto K, Nakahara T. Role of Glial Cells in μ-Opioid Receptor-Mediated Vasodilation in the Rat Retina. Curr Eye Res. 43 :350-356, 2018. doi: 10.1080/02713683.2017.1403631.

  34. 156. Nakahara T, Morita A, Yagasaki R, Mori A, Sakamoto K. Mammalian Target of Rapamycin (mTOR) as a Potential Therapeutic Target in Pathological Ocular Angiogenesis. Biol Pharm Bull. 40: 2045-2049, 2017. doi: 10.1248/bpb.b17-00475.

  35. 155. Sakamoto K, Okuwaki T, Ushikubo H, Mori A, Nakahara T, Ishii K. Activation inhibitors of nuclear factor kappa B protect neurons against the NMDA-induced damage in the rat retina. J Pharmacol Sci. 135: 72-80, 2017. doi: 10.1016/j.jphs.2017.09.031.

  36. 154. Mori A, Higashi K, Wakao S, Sakamoto K, Ishii K, Nakahara T. Probucol prevents the attenuation of β2-adrenoceptor-mediated vasodilation of retinal arterioles in diabetic rats. Naunyn Schmiedebergs Arch Pharmacol. 390: 1247-1253, 2017. doi: 10.1007/s00210-017-1423-y.

  37. 153. Kurauchi Y, Mokudai K, Morita M, Kamimura A, Mori A, Sakamoto K, Nakahara T, Ishii K. l-Citrulline improves cerebral blood flow in migraine model rats. J Funct Foods 38 part A: 540-544, 2017. doi: 10.1016/j.jff.2017.09.054.

  38. 152. Sakamoto K, Okuwaki T, Ushikubo H, Mori A, Nakahara T, Ishii K. Activation inhibitors of nuclear factor kappa B protect neurons against the NMDA-induced damage in the rat retina. J Pharmacol Sci. 135: 72-80, 2017. doi: 10.1016/j.jphs.2017.09.031.

  39. 151. Sakamoto K, Kuroki T, Sagawa T, Ito H, Mori A, Nakahara T, Ishii K. Opioid receptor activation is involved in neuroprotection induced by TRPV1 channel activation against excitotoxicity in the rat retina. Eur J Pharmacol. 812: 57-63, 2017. doi: 10.1016/j.ejphar.2017.07.002.

  40. 150. Kurauchi Y, Kinoshita R, Mori A, Sakamoto K, Nakahara T, Ishii K. MEK/ERK- and calcineurin/NFAT-mediated mechanism of cerebral hyperemia and brain injury following NMDA receptor activation. Biochem Biophys Res Commun. 488: 329-334, 2017. doi: 10.1016/j.bbrc.2017.05.043.

  41. 149. Someya E, Mori A, Sakamoto K, Ishii K, Nakahara T. Stimulation of μ-opioid receptors dilates retinal arterioles by neuronal nitric oxide synthase-derived nitric oxide in rats. Eur J Pharmacol. 803: 124-129, 2017. doi: 10.1016/j.ejphar.2017.03.043.

  42. 148. Mori A, Sekito A, Sakamoto K, Ishii K, Nakahara T.  Stimulation of β1- and β2-adrenoceptors dilates retinal blood vessels in rats.  Naunyn Schmiedebergs Arch Pharmacol. 390: 527-533, 2017. doi: 10.1007/s00210-017-1349-4.

  43. 147. Kurauchi Y, Mokudai K, Mori A, Sakamoto K, Nakahara T, Morita M, Kamimura A, Ishii K. l-Citrulline ameliorates cerebral blood flow during cortical spreading depression in rats: Involvement of nitric oxide- and prostanoids-mediated pathway. J Pharmacol Sci. 133: 146-155, 2017. doi: 10.1016/j.jphs.2017.02.004.

  44. 146. Mori A, Ishikawa E, Amano T, Sakamoto K, Nakahara T. Anti-diabetic drug metformin dilates retinal blood vessels through activation of AMP-activated protein kinase in rats. Eur J Pharmacol. 798:66-71, 2017. doi: 10.1016/j.ejphar.2017.01.003.

  45. 145. Morita A, Ushikubo H, Mori A, Arima S, Sakamoto K, Nagamitsu T, Ishii K, Nakahara T. A delay in vascularization induces abnormal astrocyte proliferation and migration in the mouse retina. Dev Dyn. 246: 186-200, 2017.

  46. 144. Morita A, Ushikubo H, Mori A, Sakamoto K, Nakahara T. Exposure to high-concentration oxygen in the neonatal period induces abnormal retinal vascular patterning in mice. Birth Defects Res B Dev Reprod Toxicol. 107(6): 216-224, 2016. doi: 10.1002/bdrb.21187.

  47. 143. Sakamoto K, Murakami Y, Sawada S, Ushikubo H, Mori A, Nakahara T, Ishii K. Apelin-36 is protective against N-methyl-D-aspartic-acid-induced retinal ganglion cell death in the mice. Eur J Pharmacol. 791: 213-220, 2016. doi: 10.1016/j.ejphar.2016.08.036.

  48. 142. Hayashi I, Aoki Y, Ushikubo H, Asano D, Mori A, Sakamoto K, Nakahara T, Ishii K. Protective effects of PF-4708671 against N-methyl-d-aspartic acid-induced retinal damage in rats. Fundam Clin Pharmacol. 30(6): 529-536, 2016. doi: 10.1111/fcp.12216.

  49. 141. Nakano A, Nakahara T, Mori A, Ushikubo H, Sakamoto K, Ishii K. Short-term treatment with VEGF receptor inhibitors induces retinopathy of prematurity-like abnormal vascular growth in neonatal rats. Exp Eye Res. 143: 120-131, 2016. doi: 10.1016/j.exer.2015.10.016.

  50. 140. Hayashi I, Aoki Y, Asano D, Ushikubo H, Mori A, Sakamoto K, Nakahara T, Ishii K. Protective Effects of Everolimus against N-Methyl-D-aspartic Acid-Induced Retinal Damage in Rats. Biol Pharm Bull. 38: 1765-1771, 2015. doi: 10.1248/bpb.b15-00464.

  51. 139. Mori A, Suzawa H, Sakamoto K, Nakahara T, Ishii K. Vasodilator Effects of Elcatonin, a Synthetic Eel Calcitonin, on Retinal Blood Vessels in Rats. Biol Pharm Bull. 38: 1536-1541, 2015. doi: 10.1248/bpb.b15-00303.

  52. 138. Iizuka N, Nakahara T, Ushikubo H, Mori A, Sakamoto K, Ishii K. Retinal region-dependent susceptibility of capillaries to high-concentration oxygen exposure and vascular endothelial growth factor receptor inhibition in neonatal mice. J Pharmacol Sci. J Pharmacol Sci. 129: 107-118, 2015. doi: 10.1016/j.jphs.2015.08.010.

  53. 137. Mori A, Namekawa R, Hasebe M, Saito M, Sakamoto K, Nakahara T, Ishii K. Involvement of prostaglandin I2 in nitric oxide-induced vasodilation of retinal arterioles in rats. Eur J Pharmacol. 764: 249-255, 2015. doi: 10.1016/j.ejphar.2015.07.009.

  54. 136. Shirai Y, Mori A, Nakahara T, Sakamoto K, Ishii K. Deferiprone Protects against Photoreceptor Degeneration Induced by Tunicamycin in the Rat Retina. Biol Pharm Bull. 38(7): 1076-1080, 2015. doi: 10.1248/bpb.b15-00185.

  55. 135. Sakamoto K, Mizuta A, Fujimura K, Kurauchi Y, Mori A, Nakahara T, Ishii K. High-mobility group Box-1 is involved in NMDA-induced retinal injury the in rat retina. Exp Eye Res. 137: 63-70, 2015. doi: 10.1016/j.exer.2015.06.003.

  56. 134. Asami Y, Nakahara T, Asano D, Kurauchi Y, Mori A, Sakamoto K, Ishii K. Age-Dependent Changes in the Severity of Capillary Degeneration in Rat Retina Following N-Methyl-D-Aspartate-Induced Neurotoxicity. Curr Eye Res. 40(5): 549-553, 2015. doi: 10.3109/02713683.2014.933851.

  57. 133. Mori A, Morita M, Morishita K, Sakamoto K, Nakahara T, Ishii K. L-Citrulline dilates rat retinal arterioles via nitric oxide- and prostaglandin-dependent pathways in vivo. J Pharmacol Sci. 127(4): 419-423, 2015. doi: 10.1016/j.jphs.2015.02.012.

  58. 132. Sakamoto K, Endo K, Suzuki T, Fujimura K, Kurauchi Y, Mori A, Nakahara T, Ishii K. P2X7 receptor antagonists protect against N-methyl-d-aspartic acid-induced neuronal injury in the rat retina. Eur J Pharmacol. 756: 52-58, 2015. doi: 10.1016/j.ejphar.2015.03.008.

  59. 131. Nakahara T, Hoshino M, Hoshino S, Mori A, Sakamoto K, Ishii K. Structural and functional changes in retinal vasculature induced by retinal ischemia-reperfusion in rats. Exp Eye Res. 135: 134-145, 2015. doi: 10.1016/j.exer.2015.02.020.

  60. 130. Mori A, Takei T, Sakamoto K, Nakahara T, Ishii K. 4-Hydroxy-2-nonenal attenuates β2-adrenoceptor-mediated vasodilation of rat retinal arterioles. Naunyn Schmiedebergs Arch Pharmacol. 388(5): 575-582, 2015. doi: 10.1007/s00210-015-1099-0.

  61. 129. Aoki Y, Nakahara T, Asano D, Ushikubo H, Mori A, Sakamoto K, Ishii K. Preventive effects of rapamycin on inflammation and capillary degeneration in a rat model of NMDA-induced retinal injury. Biol Pharm Bull. 38(2): 321-324, 2015. doi: 10.1248/bpb.b14-00631.

  62. 128. Mori A, Hanada M, Sakamoto K, Nakahara T, Ishii K. Impaired retinal vasodilator response to acetylcholine in a rat model of NMDA-induced retinal degeneration. J Pharmacol Sci. 127(2): 211-216, 2015. doi: 10.1016/j.jphs.2014.12.014.

  63. 127. Asano D, Nakahara T, Mori A, Sakamoto K, Ishii K. Regression of retinal capillaries following N-methyl-D-aspartate-induced neurotoxicity in the neonatal rat retina. J Neurosci Res. 93(2): 380-390, 2015.

  64. 126. Sakamoto K, Mori A, Nakahara T, Morita M, Ishii K. Effect of Long-Term treatment of L-Ornithine on visual function and retinal histology in the rats. Biol Pharm Bull. 38(1): 139-143, 2015.

  65. 125. Morita A, Nakahara T, Ushikubo H, Mori A, Sakamoto K, Ishii K. Treatment of newborn mice with inhibitors of vascular endothelial growth factor receptor tyrosine kinase induces abnormal retinal vascular patterning. Biol Pharm Bull. 37: 1986-1989, 2014.

  66. 124. Yagasaki R, Nakahara T, Mori A, Sakamoto K, Ishii K. Effects of mTOR inhibition on normal retinal vascular development in the mouse. Exp Eye Res. 129: 127-134, 2014.

  67. 123. Yagasaki R, Nakahara T, Ushikubo H, Mori A, Sakamoto K, Ishii K. Anti-angiogenic effects of mammalian target of rapamycin inhibitors in a mouse model of oxygen-induced retinopathy. Biol Pharm Bull. 37: 1838-1842, 2014.

  68. 122. Morita A, Nakahara T, Abe N, Kurauchi Y, Mori A, Sakamoto K, Nagamitsu T, Ishii K. Treatment of Mid-Pregnant Mice with KRN633, an Inhibitor of Vascular Endothelial Growth Factor Receptor Tyrosine Kinase, Induces Abnormal Retinal Vascular Patterning in Their Newborn Pups. Birth Defects Res B Dev Reprod Toxicol. 101(4):293-299, 2014.

  69. 121. Sakamoto K, Kuroki T, Okuno Y, Sekiya H, Watanabe A, Sagawa T, Ito H, Mizuta A, Mori A, Nakahara T, Ishii K. Activation of the TRPV1 channel attenuates N-methyl-D-aspartic acid-induced neuronal injury in the rat retina. Eur J Pharmacol. 733:13-22, 2014.

  70. 120. Ichikawa A, Nakahara T, Kurauchi Y, Mori A, Sakamoto K, Ishii K. Rapamycin prevents N-methyl-D-aspartate-induced retinal damage through an ERK-dependent mechanism in rats. J Neurosci Res. 92(6):692-702, 2014.

  71. 119. Aoki M, Kurauchi Y, Mori A, Nakahara T, Sakamoto K, Ishii K. Comparison of the effects of single doses of elcatonin and pregabalin on oxaliplatin-induced cold and mechanical allodynia in rats. Biol Pharm Bull. 37(2):322-326, 2014.

  72. 118. Kuroki T, Mori A, Nakahara T, Sakamoto K, Ishii K. Histological protection by nilvadipine against neurotoxicity induced by NOC12, a nitric oxide donor, in the rat retina. Biol Pharm Bull. 37(2):306-310, 2014.

  73. 117. Morita A, Nakahara T, Abe N, Kurauchi Y, Mori A, Sakamoto K, Nagamitsu T, Ishii K. Effects of pre- and post-natal treatment with KRN633, an inhibitor of vascular endothelial growth factor receptor tyrosine kinase, on retinal vascular development and patterning in mice. Exp Eye Res. 120:127-137, 2014.

  74. 116. Sakamoto K, Suzuki Y, Kurauchi Y, Mori A, Nakahara T, Ishii K. Hydrogen sulfide attenuates NMDA-induced neuronal injury via its anti-oxidative activity in the rat retina. Exp Eye Res. 120:90-96, 2014.

  75. 115. Ueda K, Nakahara T, Akanuma K, Mori A, Sakamoto K, Ishii K. Differential effects of LY294002 and wortmannin on neurons and vascular endothelial cells in the rat retina. Pharmacol Rep. 65(4):854-862, 2013.

  76. 114.Naruoka T, Nakahara T, Tsuda Y, Kurauchi Y, Mori A, Sakamoto K, Nishihira J, Ishii K. ISO-1, a macrophage migration inhibitory factor antagonist, prevents N-methyl-D-aspartate-induced retinal damage. Eur J Pharmacol. 718(1-3):138-144, 2013.

  77. 113.Abe N, Nakahara T, Morita A, Wada Y, Mori A, Sakamoto K, Nagamitsu T, Ishii K.  KRN633, an Inhibitor of Vascular Endothelial Growth Factor Receptor Tyrosine Kinase, Induces Intrauterine Growth Restriction in Mice. Birth Defects Res B Dev Reprod Toxicol. 98(4):297-303, 2013.

  78. 112.Aoki M, Mori A, Nakahara T, Sakamoto K, Ishii K. Salmon calcitonin reduces oxaliplatin-induced cold and mechanical allodynia in rats. Biol Pharm Bull. 2013;36(2):326-9.

  79. 111.Wada Y, Ozaki H, Abe N, Mori A, Sakamoto K, Nagamitsu T, Nakahara T, Ishii K. Role of vascular endothelial growth factor in maintenance of pregnancy in mice. Endocrinology. 2013 Feb;154(2):900-10.

  80. 110.Yoshihara T, Yonoki Y, Saito M, Nakahara T, Sakamoto K, Ishii K. Agonist-induced receptor internalization in Chinese hamster ovary cells stably co-expressing β(1)- and β(2)-adrenergic receptors. Biol Pharm Bull. 2013;36(1):114-9.

  81. 109. Ueda K, Nakahara T, Mori A, Sakamoto K, Ishii K. Protective effects of TGF-β inhibitors in a rat model of NMDA-induced retinal degeneration. Eur J Pharmacol. 2013 Jan 15;699(1-3):188-93.

  82. 108. Tsuda Y, Nakahara T, Ueda K, Mori A, Sakamoto K, Ishii K. Effect of nafamostat on N-methyl-D-aspartate-induced retinal neuronal and capillary degeneration in rats. Biol Pharm Bull. 2012;35(12):2209-13.

  83. 107. Aoki M, Mori A, Nakahara T, Sakamoto K, Ishii K. Effect of synthetic eel calcitonin, elcatonin, on cold and mechanical allodynia induced by oxaliplatin and paclitaxel in rats. Eur J Pharmacol. 2012 Dec 5;696(1-3):62-9.

  84. 106. Oikawa F, Nakahara T, Akanuma K, Ueda K, Mori A, Sakamoto K, Ishii K. Protective effects of the β3-adrenoceptor agonist CL316243 against N-methyl-D-aspartate-induced retinal neurotoxicity.

  85. 105. Kawakubo K, Mori A, Sakamoto K, Nakahara T, Ishii K. GP-1447, an inhibitor of aldose reductase, prevents the progression of diabetic cataract in rats. Biol Pharm Bull. 2012;35(6):866-72.

  86. 104. Yunoki M, Nakahara T, Moriuchi H, Sakamoto K, Ishii K. The relaxant action of nicorandil in bovine tracheal smooth muscle. Pharmacology. 2012;89(5-6):327-32.

  87. 103. Mori A, Hanada M, Sakamoto K, Nakahara T, Ishii K. Noradrenaline contracts rat retinal arterioles via stimulation of α(1A)- and α(1D)-adrenoceptors. Eur J Pharmacol. 2011 Dec 30;673(1-3):65-9. Epub 2011 Oct 21.

  88. 102. Mori A, Nakahara T, Sakamoto K, Ishii K. Role of β3-adrenoceptors in regulation of retinal vascular tone in rats. Naunyn Schmiedebergs Arch Pharmacol. 2011 Dec;384(6):603-8. Epub 2011 Sep 8.

  89. 101. Mori A, Suzuki S, Sakamoto K, Nakahara T, Ishii K. Vasodilation of retinal arterioles induced by activation of BKCa channels is attenuated in diabetic rats. Eur J Pharmacol. 2011 Nov 1;669(1-3):94-9. Epub 2011 Aug 19.

  90. 100. Shimizu N, Nakahara T, Tsuda Y, Mori A, Sakamoto K, Ishii K. Involvement of bradykinin in trypsin-induced urinary bladder contraction in cyclophosphamide-treated rats. Biol Pharm Bull. 2011;34(7):1122-5.

  91. 99. Sakamoto K, Ohki K, Saito M, Nakahara T, Ishii K. Small molecule cyclin-dependent kinase inhibitors protect against neuronal cell death in the ischemic-reperfused rat retina. J Ocul Pharmacol Ther. 2011 Oct;27(5):419-25. Epub 2011 Jun 29.

  92. 98. Tsuda Y, Nakahara T, Mori A, Sakamoto K, Ishii K. Resveratrol prevents bradykinin-induced contraction of rat urinary bladders by decreasing prostaglandin production and calcium influx. Eur J Pharmacol. 2011 Sep;666(1-3):189-95. Epub 2011 May 23.

  93. 97. Sakamoto K, Nakahara T, Ishii K. Rho-Rho kinase pathway is involved in the protective effect of early ischemic preconditioning in the rat heart. Biol Pharm Bull. 2011;34(1):156-9.

  94. 96.  Mori A, Suzuki S, Sakamoto K, Nakahara T, Ishii K. BMS-191011, an opener of large-conductance Ca2+-activated potassium channels, dilates rat retinal arterioles in vivo. Biol Pharm Bull. 2011;34(1):150-2.

  95. 95. Shimizu N, Nakahara T, Kubota Y, Sakamoto K, Ishii K. Contribution of cyclooxygenase-dependent mechanisms to contractile responses to donepezil in the rat urinary bladder. Pharmacology. 2010;86(5-6):281-6.

  96. 94. Mori A, Suzuki S, Sakamoto K, Nakahara T, Ishii K. Role of calcium-activated potassium channels in acetylcholine-induced vasodilation of rat retinal arterioles in vivo. Naunyn Schmiedebergs Arch Pharmacol. 2011 Jan;383(1):27-34.

  97. 93. Ueda K, Nakahara T, Hoshino M, Mori A, Sakamoto K, Ishii K. Retinal blood vessels are damaged in a rat model of NMDA-induced retinal degeneration. Neurosci Lett. 2010 Nov 12;485(1):55-9.

  98. 92. Mori A, Miwa T, Sakamoto K, Nakahara T, Ishii K. Pharmacological evidence for the presence of functional beta(3)-adrenoceptors in rat retinal blood vessels. Naunyn Schmiedebergs Arch Pharmacol. 2010 Aug;382(2):119-26. Epub 2010 May 26.

  99. 91. Sakamoto K, Hiraiwa M, Saito M, Nakahara T, Sato Y, Nagao T, Ishii K. Protective effect of all-trans retinoic acid on NMDA-induced neuronal cell death in rat retina. Eur J Pharmacol. 2010 Jun 10;635(1-3):56-61.

  100. 90. Wada Y, Ozaki H, Abe N, Nagamitsu T, Ohta H, Nakahara T, Ishii K. Effects of KRN633, an inhibitor of vascular endothelial growth factor receptor-2 tyrosine kinase, on vascular development of placenta and fetus of mid-pregnancy in mice. J Pharmacol Sci. 2010 Mar 19;112(3):290-8.

  101. 89. Sakamoto K, Ohki K, Saito M, Nakahara T, Ishii K. Histological protection by donepezil against neurodegeneration induced by ischemia-reperfusion in the rat retina. J Pharmacol Sci. 2010 Mar 19;112(3):327-35.

  102. 88. Mori A, Saigo O, Sakamoto K, Nakahara T, Ishii K. Hyperglycemia impairs acetylcholine-induced vasodilation of retinal arterioles through polyol pathway-independent mechanisms in rats. J Pharmacol Sci. 2010 Mar 19;112(3):336-42.

  103. 87. Noguchi M, Mori A, Sakamoto K, Nakahara T, Ishii K. Vasodilator effects of flunarizine on retinal blood vessels in anesthetized rats. Biol Pharm Bull. 2009 Dec;32(12):2068-71.

  104. 86.Noguchi M, Mori A, Sakamoto K, Nakahara T, Ishii K. Vasodilator effects of ibudilast on retinal blood vessels in anesthetized rats. Biol Pharm Bull. 2009 Nov;32(11):1924-7.

  105. 85. Tsuchida K, Saito M, Nakahara T, Sakamoto K, Ishii K. Upregulation of Intestinal NaPi-IIb Co-Transporter Gene Expression by Neuropeptide Y in Human Intestinal Caco-2 Cells. The Open Gastroenterol J. 3: 19-22, 2009.

  106. 84. Ogawa N, Mori A, Hasebe M, Hoshino M, Saito M, Sakamoto K, Nakahara T, Ishii K. Nitric oxide dilates rat retinal blood vessels by cyclooxygenase-dependent mechanisms. Am J Physiol Regul Integr Comp Physiol. 2009 Oct;297(4):R968-77.

  107. 83. Kojima N, Saito M, Mori A, Sakamoto K, Nakahara T, Ishii K. Role of cyclooxygenase in vasodilation of retinal blood vessels induced by bradykinin in Brown Norway rats. Vascul Pharmacol. 2009 Aug-Sep;51(2-3):119-24.\

  108. 82. Mori A, Saigo O, Hanada M, Nakahara T, Ishii K. Hyperglycemia accelerates impairment of vasodilator responses to acetylcholine of retinal blood vessels in rats. J Pharmacol Sci. 2009 Jun;110(2):160-8.

  109. 81. Mori A, Ishii T, Kuroki T, Shigeta N, Sakamoto K, Nakahara T, Ishii K. The prostanoid EP(2) receptor agonist ONO-AE1-259-01 protects against glutamate-induced neurotoxicity in rat retina. Eur J Pharmacol. 2009 Aug 15;616(1-3):64-7.

  110. 80. Sakamoto K, Kawakami T, Shimada M, Yamaguchi A, Kuwagata M, Saito M, Nakahara T, Ishii K. Histological protection by cilnidipine, a dual L/N-type Ca(2+) channel blocker, against neurotoxicity induced by ischemia-reperfusion in rat retina. Exp Eye Res. 2009 May;88(5):974-82.

  111. 79. Miwa T, Mori A, Nakahara T, Ishii K. Intravenously administered phosphodiesterase 4 inhibitors dilate retinal blood vessels in rats. Eur J Pharmacol. 2009 Jan 5;602(1):112-6.

  112. 78. Sakamoto K, McCluskey M, Wensel TG, Naggert JK, Nishina PM. New mouse models for recessive retinitis pigmentosa caused by mutations in the Pde6a gene. Hum Mol Genet. 2009 Jan 1;18(1):178-92.

  113. 77. Saito M, Ueo M, Kametaka S, Saigo O, Uchida S, Hosaka H, Sakamoto K, Nakahara T, Mori A, Ishii K. Attenuation of cataract progression by A-3922, a dihydrobenzofuran derivative, in streptozotocin-induced diabetic rats. Biol Pharm Bull. 2008 Oct;31(10):1959-63.

  114. 76. Nakazawa T, Sato A, Mori A, Saito M, Sakamoto K, Nakahara T, Ishii K. Beta-adrenoceptor-mediated vasodilation of retinal blood vessels is reduced in streptozotocin-induced diabetic rats. Vascul Pharmacol. 2008 Aug-Sep;49(2-3):77-83.

  115. 75. Kametaka S, Kasahara T, Ueo M, Takenaka M, Saito M, Sakamoto K, Nakahara T, Ishii K. Effect of nifedipine on severe experimental cataract in diabetic rats. J Pharmacol Sci. 2008 Apr;106(4):651-8.

  116. 74. Kametaka S, Kasahara T, Ueo M, Takenaka M, Saito M, Sakamoto K, Nakahara T, Ishii K. A novel high resolution in vivo digital imaging system for the evaluation of experimental cataract in diabetic rats. J Pharmacol Sci. 2008 Jan;106(1):144-51.

  117. 73. Nakazawa T, Mori A, Saito M, Sakamoto K, Nakahara T, Ishii K. Vasodilator effects of adenosine on retinal arterioles in streptozotocin-induced diabetic rats. Naunyn Schmiedebergs Arch Pharmacol. 2008 Feb;376(6):423-30.

  118. 72. Mori A, Saito M, Sakamoto K, Narita M, Nakahara T, Ishii K. Stimulation of prostanoid IP and EP(2) receptors dilates retinal arterioles and increases retinal and choroidal blood flow in rats. Eur J Pharmacol. 2007 Sep 10;570(1-3):135-41.

  119. 71. Okamura N, Saito M, Mori A, Sakamoto K, Kametaka S, Nakahara T, Ishii K. Vasodilator effects of fasudil, a Rho-kinase inhibitor, on retinal arterioles in stroke-prone spontaneously hypertensive rats. J Ocul Pharmacol Ther. 2007 Jun;23(3):207-12.

  120. 70. Shimizu N, Nakahara T, Saito M, Ishii K. Role of capsaicin-sensitive sensory nerves in protease-activated receptor-2-mediated contraction of rat urinary bladder. Eur J Pharmacol. 2007 Aug 13;569(1-2):145-8.

  121. 69. Ogawa N, Saito M, Mori A, Sakamoto K, Kametaka S, Nakahara T, Ishii K. Vasodilator effect of nicorandil on retinal blood vessels in rats. Naunyn Schmiedebergs Arch Pharmacol. 2007 Jul;375(5):323-8.

  122. 68. Kaneko Y, Saito M, Mori A, Sakamoto K, Kametaka S, Nakahara T, Ishii K. Vasodilation of retinal arteriole mediated by corticotropin-releasing factor receptor is impaired in streptozotocin-induced diabetic rats. Biol Pharm Bull. 2007 May;30(5):985-9.

  123. 67. Mori A, Saito M, Sakamoto K, Nakahara T, Ishii K. Intravenously administered vasodilatory prostaglandins increase retinal and choroidal blood flow in rats. J Pharmacol Sci. 2007 Jan;103(1):103-12.

  124. 66. Budzynski E, Lee Y, Sakamoto K, Naggert JK, Nishina PM. From vivarium to bedside: lessons learned from animal models. Ophthalmic Genet. 2006 Dec;27(4):123-37.

  125. 65. Nakazawa T, Kaneko Y, Mori A, Saito M, Sakamoto K, Nakahara T, Ishii K. Attenuation of nitric oxide- and prostaglandin-independent vasodilation of retinal arterioles induced by acetylcholine in streptozotocin-treated rats. Vascul Pharmacol. 2007 Mar;46(3):153-9.

  126. 64. Kaneko Y, Saito M, Mori A, Sakamoto K, Nakahara T, Ishii K. Vasodilator effects of adrenomedullin on retinal arterioles in streptozotocin-induced diabetic rats. J Ocul Pharmacol Ther. 2006 Oct;22(5):317-22.

  127. 63. Mancuso MR, Davis R, Norberg SM, O'Brien S, Sennino B, Nakahara T, Yao VJ, Inai T, Brooks P, Freimark B, Shalinsky DR, Hu-Lowe DD, McDonald DM. Rapid vascular regrowth in tumors after reversal of VEGF inhibition. J Clin Invest. 2006 Oct;116(10):2610-21.

  128. 62. Sakamoto K, Yonoki Y, Fujioka T, Matsumura M, Mitsuta Y, Sano M, Saito M, Nakahara T, Ishii K. Disappearance of glibenclamide-induced hypoglycemia in Wistar-Kyoto rats. Biol Pharm Bull. 2006 Mar;29(3):574-6.

  129. 61. Nakahara T, Norberg SM, Shalinsky DR, Hu-Lowe DD, McDonald DM. Effect of inhibition of vascular endothelial growth factor signaling on distribution of extravasated antibodies in tumors. Cancer Res. 2006 Feb 1;66(3):1434-45.

  130. 60. Sakamoto K, Yonoki Y, Kubota Y, Kuwagata M, Saito M, Nakahara T, Ishii K. Inducible nitric oxide synthase inhibitors abolished histological protection by late ischemic preconditioning in rat retina. Exp Eye Res. 2006 Mar;82(3):512-8.

  131. 59. Maruko T, Nakahara T, Sakamoto K, Saito M, Sugimoto N, Takuwa Y, Ishii K. Involvement of the betagamma subunits of G proteins in the cAMP response induced by stimulation of the histamine H1 receptor. Naunyn Schmiedebergs Arch Pharmacol. 2005 Aug;372(2):153-9.

  132. 58. Nakahara T, Nejishima H, Nakayama K, Ishii K. Accelerated acetylcholine metabolism in the lung after infusion of phenylephrine in dogs. Res Commun Mol Pathol Pharmacol. 2003;113-114:201-6.

  133. 57. Nakahara T, Mitani A, Kubota Y, Maruko T, Sakamoto K, Tanaka Y, Koike K, Shigenobu K, Ishii K. MaxiK channel-triggered negative feedback system is preserved in the urinary bladder smooth muscle from streptozotocin-induced diabetic rats. J Smooth Muscle Res. 2004 Jun;40(3):97-109.

  134. 56. Sakamoto K, Yonoki Y, Kuwagata M, Saito M, Nakahara T, Ishii K. Histological protection against ischemia-reperfusion injury by early ischemic preconditioning in rat retina. Brain Res. 2004 Jul 23;1015(1-2):154-60.

  135. 55. Nakahara T, Mitani A, Saito M, Sakamoto K, Ishii K. Diphenylamine-2-carboxylic acid potentiates the cyclic nucleotides-mediated relaxation of porcine coronary artery: possible involvement of the inhibitory effect on the efflux of cyclic nucleotides. Vascul Pharmacol. 2004 Feb;41(1):21-5.

  136. 54. Sakamoto K, Karikomi Y, Kubota Y, Nakahara T, Ishii K. Characterization of mexiletine as an antagonist of beta-adrenoceptor in Chinese hamster ovary cells expressing cloned human beta-adrenoceptors. Biochem Pharmacol. 2004 Mar 1;67(5):815-22.

  137. 53. Nakahara T, Maruko T, Sakamoto K, Ishii K. Influence of receptor number on the cAMP response to forskolin in Chinese hamster ovary cells transfected with human beta2-adrenoceptor. Biol Pharm Bull. 2004 Feb;27(2):239-41.

  138. 52. Nakahara T, Kubota Y, Saito M, Sakamoto K, Ishii K. Protease-activated receptor-2-mediated contraction of urinary bladder is enhanced in cyclophosphamide-treated rats. Naunyn Schmiedebergs Arch Pharmacol. 2004 Feb;369(2):212-9.

  139. 51. Kiyoshi A, Ishikawa T, Hayashi K, Iwatsuki Y, Ishii K, Nakayama K. Rhythmical contractions in pulmonary arteries of monocrotaline-induced pulmonary hypertensive rats. Pflugers Arch. 2003 Nov;447(2):142-9.

  140. 50. Yunoki M, Nakahara T, Mitani A, Maruko T, Kubota Y, Sakamoto K, Ishii K. Lidocaine attenuates muscarinic receptor-mediated inhibition of adenylyl cyclase in airway smooth muscle. Eur J Pharmacol. 2003 May 30;470(1-2):65-71.

  141. 49. Moriuchi H, Nakahara T, Maruko T, Sakamoto K, Ishii K. Relaxant effect of YM976, a novel phosphodiesterase 4 inhibitor, on bovine tracheal smooth muscle. Eur J Pharmacol. 2003 May 30;470(1-2):57-64.

  142. 48. Kubota Y, Nakahara T, Mitani A, Maruko T, Saito M, Sakamoto K, Ishii K. Possible involvement of Ca2+-independent phospholipase A2 in protease-activated receptor-2-mediated contraction of rat urinary bladder. Naunyn Schmiedebergs Arch Pharmacol. 2003 Jun;367(6):588-91.

  143. 47. Nakahara T, Kubota Y, Sakamoto K, Ishii K. The role of cholinesterases in rat urinary bladder contractility. Urol Res. 2003 Jul;31(3):223-6.

  144. 46. Chino D, Fujita Y, Ishii K, Nakayama K. Effects of DX-9065a, an inhibitor of factor Xa, on ellagic acid-induced plantar skin thrombosis assessed in tetrodotoxin- and N(omega)-nitro-L-arginine-treated rats. J Pharmacol Sci. 2003 Apr;91(4):319-29.

  145. 45. Kubota Y, Nakahara T, Mitani A, Maruko T, Sakamoto K, Ishii K. Augmentation of rat urinary bladder relaxation mediated by beta1-adrenoceptors in experimental diabetes. Eur J Pharmacol. 2003 Apr 25;467(1-3):191-5.

  146. 44. Mitani A, Nakahara T, Sakamoto K, Ishii K. Expression of multidrug resistance protein 4 and 5 in the porcine coronary and pulmonary arteries. Eur J Pharmacol. 2003 Apr 11;466(1-2):223-4.

  147. 43. Yunoki M, Nakahara T, Mitani A, Sakamoto K, Ishii K. Role of the M2 muscarinic receptor pathway in lidocaine-induced potentiation of the relaxant response to atrial natriuretic peptide in bovine tracheal smooth muscle. Naunyn Schmiedebergs Arch Pharmacol. 2003 Jan;367(1):76-9.

  148. 42. Nakahara T, Kubota Y, Mitani A, Maruko T, Sakamoto K, Ishii K. Protease-activated receptor-2-mediated contraction in the rat urinary bladder: the role of urinary bladder mucosa. Naunyn Schmiedebergs Arch Pharmacol. 2003 Feb;367(2):211-3.

  149. 41. Nakahara T, Yunoki M, Mitani A, Sakamoto K, Ishii K. Stimulation of muscarinic M2 receptors inhibits atrial natriuretic peptide-mediated relaxation in bovine tracheal smooth muscle. Naunyn Schmiedebergs Arch Pharmacol. 2002 Oct;366(4):376-9.

  150. 40. Nakahara T, Yunoki M, Moriuchi H, Mitani A, Sakamoto K, Ishii K. Relaxation and potentiation of cGMP-mediated response by ibudilast in bovine tracheal smooth muscle. Naunyn Schmiedebergs Arch Pharmacol. 2002 Sep;366(3):262-9.

  151. 39. Kubota Y, Nakahara T, Yunoki M, Mitani A, Maruko T, Sakamoto K, Ishii K. Inhibitory mechanism of BRL37344 on muscarinic receptor-mediated contractions of the rat urinary bladder smooth muscle. Naunyn Schmiedebergs Arch Pharmacol. 2002 Sep;366(3):198-203.

  152. 38. Tanaka Y, Kamibayashi M, Yamashita Y, Imai T, Tanaka H, Nakahara T, Ishii K, Shigenobu K. Evidence for the possible involvement of Ca2+ entry blockade in the relaxation by class I antiarrhythmic drugs in the isolated pig coronary smooth muscle. Naunyn Schmiedebergs Arch Pharmacol. 2002 Jan;365(1):56-66.

  153. 37. Sato R, Sakamoto K, Yamazaki J, Nagao T. Differences in protective profiles of diltiazem isomers in ischemic and reperfused guinea pig hearts. Eur J Pharmacol. 2002 Jan 11;434(3):125-31.

  154. 36. Sakamoto K, Kuwagata M, Nakahara T, Ishii K.. Late preconditioning in rat retina: involvement of adenosine and ATP-sensitive K+ channel. Eur. J. Pharmacol. 418:89-93, 2001.

  155. 35. Nakahara T, Yunoki M, Moriuchi H, Sakamoto K, Ishii K. Lidocaine potentiates atrial natriuretic peptide-induced relaxation of bovine tracheal smooth muscle. Eur. J. Pharmacol. 425:129-133, 2001.

  156. 34. Nakahara T, Moriuchi H, Tanaka Y, Yunoki M, Kubota Y, Sakamoto K, Shigenobu K, Ishii K. Role of K+ channels in N-acetylprocainamide-induced relaxation of bovine tracheal smooth muscle. Eur. J. Pharmacol. 415:73-78, 2001.

  157. 33. Nakahara T, Kubota Y, Sakamoto K, Moriuchi H, Yunoki M, Ishii K. Mexiletine inhibits pharmacological actions of salbutamol through blockade of beta2-adrenoceptors in bovine tracheal smooth muscle. Naunyn-Schmiedeberg's Arch. Pharmacol. 364:409-413, 2001.

  158. 32. Kodaira H, Ishihara K, Hotta K, Kagoshima M, Shimada H, Ishii K.　Reaction of various lectins to mucin derived from the different layers of rat gastric mucosa: Comparison of enzyme-linked lectin binding assay with lectinhistochemistry.　Biol. Pharm. Bull. 23:1173-1179,　2000.

  159. 31. Sakamoto K, Ishikawa M, Koga K, Urushidani T, Nagao T.　Energy preserving effect of l-cis diltiazem in isolated ischemic and reperfused guinea pig hearts: a 31P-NMR study.　Jpn. J. Pharmacol. 83:225-32,　2000.

  160. 30. Nakahara T, Yunoki M, Moriuchi H, Sakamoto K, Ishii K.　Lidocaine potentiates the relaxant effects of cAMP-elevating agents in bovine tracheal smooth muscle. Naunyn-Schmiedeberg's Arch. Pharmacol.　361:605-609,　2000.

  161. 29. Yoshimura R, Sato T, Kawada T, Shishido T, Inagaki M, Miyano H, Nakahara T, Miyashita H, Takaki H, Tatewaki T, Yanagiya Y, Sugimachi M, Sunagawa K.　Increased brain angiotensin receptor in rats with chronic high-output heart failure.　J. Card. Fail.　6:66-72,　2000.

  162. 28. Nakahara T, Moriuchi H, Yunoki M, Kubota Y, Tanaka Y, Sakamoto K, Shigenobu K, Ishii K　Involvement of K+ channel in procainamide-induced relaxation of bovine tracheal smooth muscle.　Eur. J. Pharmacol.　402:143-149,　2000.

  163. 27. Nakahara T, Moriuchi H, Yunoki M, Sakamoto K, Ishii K　Y-27632 potentiates relaxant effects of beta2-adrenoceptor agonists in bovine tracheal smooth muscle.　Eur. J. Pharmacol. 389:103-106,　2000.

  164. 26. Tanaka Y, Hayakawa S, Imai T, Akutsu A, Hirano H, Tanaka H, Nakahara T, Ishii K, Shigenobu K.　Possible involvement of endothelium-derived hyperpolarizing factor (EDHF) in the depressor responses to platelet-activating factor (PAF) in rats.　Br. J. Pharmacol.　131:1113-1120,　2000.

  165. 25. Miyashita H, Sugimachi M, Sato T, Kawada T, Shishido T, Nakahara T, Yoshimura R, Takaki H, Miyano H, Sunagawa K.　A novel servo control system that imposes desired aortic input impedance on the in situ rat heart.　Am. J. Physiol.　278:H998-H1007,　2000.

  166. 24. Chino D, Akimaru S, Kataha K, Ishii K, Nakayama K. Specific augmentation of plantar skin blood flow by Lipo-PGE1 assessed in tetrodotoxin- and NG-nitro-L-arginine-treated rats. J. Cardiovas. Pharmacol.　35: 630-637, 2000.

  167. 23. Sakamoto K, Urushidani T, Nagao T. Translocation of HSP27 to sarcomere induced by ischemic preconditioning in isolated rat hearts. Biochem. Biophys. Res. Commun. 269: 137-142, 2000.

  168. 22. Obara K, Hata S, Sato K, Koide M, Ishii K, Nakayama K. Contractile potentiation by endothelin-1 involves protein kinase C-delta activity in porcine coronary artery. Jpn. J. Physiol. 49: 175-183, 1999.

  169. 21. Matsuura N, Ishikawa T, Abe S, Yuyama H, Sugino F, Ishii K, Nakayama K. Nitric oxide-cyclic GMP system potentiates glucose-induced rise in cytosolic Ca2+ concentration in rat pancreatic beta-cells. Life Sci. 65: 1515-1522, 1999.

  170. 20. Nakayama K, Fukuta Y, Kiyoshi A, Iwatsuki Y, Ishii K, Ishikawa T, Iida M, Iwata H, Enomoto M. (+)-[3H] isradipine and [3H] glybenclamide bindings to heart and lung membranes from rats with monocrotaline-induced pulmonary hypertension. Jpn. J. Pharmacol. 81: 176-184, 1999.

  171. 19. Nakayama K, Horikawa N, Ogata T, Kohno F, Ishii K, Kubo K, Imabeppu S. Arteriolar and venular vasodilating properties of benodipine hydrochloride, a 1,4-dihydropyridine Ca2+ antagonist with long-lasting action, assessed in rat mesenteric microcirculation. J. Cardiovasc. Pharmacol. 33: 540-548, 1999.

  172. 18. Nishida M, Urushidani T, Sakamoto K, Nagao T. l-cis diltiazem attenuates intracellular Ca2+ overload by metabolic inhibition in guinea pig myocytes. Eur. J. Pharmacol. 385: 225-230, 1999.

  173. 17. Nishida M, Sakamoto K, Urushidani T, Nagao T. Treatment with l-cis diltiazem before reperfusion reduces infarct size in the ischemic rabbit heart in vivo. Jpn. J. Pharmacol. 80: 319-325, 1999.

  174. 16. Nakahara T, Nejishima H, Nakayama K, Ishii K. Inhibitory mechanism of NG-nitro-L-arginine on acetylcholine-induced depressor responses in dogs. Eur. J. Pharmacol. 373: 201-205, 1999.

  175. 15. Nakahara T, Kawada T, Sugimachi M, Miyano H, Sato T, Shishido T, Yoshimura R, Miyashita H, Inagaki M, Alexander Jr. J, Sunagawa K. Neuronal uptake affects dynamic characteristics of heart rate response to sympathetic stimulation Am J Physiol 277: R140-R146, 1999.

  176. 14. Kawada T, Sugimachi M, Shishido T, Miyano H, Sato T, Yoshimura R, Miyashita H, Nakahara T, Alexander Jr. J, Sunagawa K. Simultaneous identification of static and dynamic vagosympathetic interactions in regulating heart rate. Am. J. Physiol. 276: R782-R789, 1999.

  177. 13. Kodaira H, Ishihara K, Hotta K, Kagoshima M, Shimada H, Ishii K　Rat gastric mucous gel layer contains sialomucin not produced by the stomach.　Jpn. J. Pharmacol.　81:86-93, 1999.

  178. 12. Kodaira H, Mizoroki T, Shimada H, Hosono M, Ishii K, Kumazawa Y.　Potential　role of bacterial lipopolysaccharides in the development of autoimmune　gastritis induced by neonatal thymectomy. J. Endotoxin. Res. 5:269-278, 1999.

  179. 11. Horikawa N, Kataha K, Watanabe N, Ishii K, Yanaihara N, Tanaka Y, Shigenobu K, Nakayama K.　Glibenclamide-sensitive hypotension produced by helodermineassessed in the rat.　Biol. Pharm. Bull.　21:1290-1293, 1998.

  180. 10. Nakahara T, Kawada T, Sugimachi M, Miyano H, Sato T, Shishido T, Yoshimura R, Miyashita H, Sunagawa K.　Cholinesterase activity affects dynamic transduction properties from vagal stimulation to heart rate.　Am. J. Physiol.　275:R541-R547,　1998.

  181. 9. Nakahara T, Kawada T, Sugimachi M, Miyano H, Sato T, Shishido T, Yoshimura R, Miyashita H, Inagaki M, Alexander Jr. J, Sunagawa K.　Accumulation of cAMP augments dynamic vagal control of heart rate. Am. J. Physiol. 275:H562-H567, 1998.

  182. 8. Zhi-Li Huang, Mochizuki T, Watanabe H, Kagoshima M, Maeyama K.　Biphasic elevation of plasma histamine induced by water immersion stress, and their sources in rats. Eur. J. Pharmacol. 360:139 -146, 1998.

  183. 7. Tanaka Y, Horikawa N, Ishiro H, Kataha K, Nakazawa T, Watanabe N, Ishii K, Nakayama K, Yanaihara N, Shigenobu K. Glibenclamide-sensitive mechanism is involved in helodermin-produced vasodilatation in rat mesenteric artery. Res.
    Commun. Mol. Pathol. Pharmacol. 98:141-156, 1997.

  184. 6. Masumoto N, Nakayama K, Oyabe A, Uchino M, Ishii K, Obara K, Tanabe Y. Specific attenuation of the pressure-induced contraction of rat cerebral artery by herbimycin A. Eur. J. Pharmacol. 330:55-63, 1997.

  185. 5. Nakayama K, Ueta K, Tanaka Y, Tanabe Y, Ishii K. Stretch-Induced contraction of rabbit isolated pulmonary artery and the Involvement of endothelium-derived thromboxane A2. Br. J. Pharmacol. 122:199-208, 1997.

  186. 4. Nakahara T, Ishii K, Tanaka Y, Nakayama K.. Flow regulates vasodilator responses to acetylcholine in isolated canine mesenteric arterial bed. Biol. Pharm. Bull. 20:568-570, 1997.

  187. 3. Nakahara T, Ishii K, Tanaka Y, Nakayama K. Flow-dependent regulation of nitric oxide formation in the isolated canine mesenteric arterial bed. Jpn. J. Pharmacol. 74: 275-280, 1997.

  188. 2. Matsuura W, Sugimachi M, Kawada T, Sato T, Shishido T, Miyano H, Nakahara T, Ikeda Y, Alexander Jr. J, Sunagawa K. Vagal stimulation decreases left ventricular contractility mainly through negative chronotropic effect Am. J. Physiol. 273:H534-H539, 1997.

  189. 1. Nakahara T, Ishii K, Tanaka Y, Nakayama K. Infusion of pressor agents　selectively attenuate depressor response to ACh in anesthetized Dogs. Am. J. Physiol. 271:H273-H281, 1996.