スタッフ紹介


　宇井　英明（うい　ひであき）

　1967 年 4 月 23 日生

　uih@pharm.kitasato-u.ac.jp

経歴

1990. 3 慶応義塾大学理工学部応用化学科卒業
1996. 3 　同　大学院理工学研究科生体医工学専攻博士課程修了
　学位（工学）取得
1996. 3 （社）北里研究所入所
2001. 3 北里大学薬学部微生物薬品製造学教室助手に就任。（現在に至る。）

主な研究テーマ

抗感染症薬の開発（AIDS、寄生虫症などをターゲットとして）

教育・研究の抱負

所属学会

日本薬学会、日本生化学会

業績

［学術論文 - 学会誌］

  1. Masaya Imoto, Naomi Shimura, Hideaki Ui, & Kazuo Umezawa: Inhibition of EGF-induced phospholipase C activation in A431 cells by erbstatin, a tyrosine kinase inhibitor. Biochem. Biophys. Res. Commun. 173(1), 208-211, 1990
  2. Masaya Imoto, Ikuo Sujikai, Hideaki Ui, & Kazuo Umezawa: Involvement of tyrosine kinase in growth factor-induced phospholipase C activation in NIH3T3 cells. Biochim. Biophys. Acta, 1166(2-3), 188-192, 1993
  3. Hideaki Ui, Masaya Imoto, & Kazuo Umezawa: Inhibition of phosphatidylinositol-specific phospholipase C activity by fluvirucin B2, J. Antibiot., 48(5), 387-390, 1995
  4. Hideaki Ui, Toshiaki Miyake, Hironobu Iinuma, Masaya Imoto, Seiko Hattori, Masa Hamada, Tomio Takeuchi, Sumio Umezawa, & Kazuo Umezawa: A novel cyclic lipoundecapeptide, pholipeptin, isolated from Pseudomonas sp. Tetrahedron Lett., 36(41), 7479-7480, 1995
  5. Hideaki Ui, Toshiaki Miyake, Hironobu Iinuma, Masaya Imoto, Hiroshi Naganawa, Seiko Hattori, Masa Hamada, Tomio Takeuchi, Sumio Umezawa, & Kazuo Umezawa: Pholipeptin, a novel cyclic lipoundecapeptide from Pseudomonas fluorescens. J. Org. Chem., 62(1), 103-108, 1997
  6. Fang Fang, Hideaki Ui, Kazuro Shiomi, Rokuro Masuma, Yuuichi Yamaguchi, Cheng Gang Zhang, Xian Wu Zhang, Yoshitake Tanaka, & Satoshi Omura: Two new components of aspochalasins produced by Aspergillus sp. J. Antibiot., 50(11), 919-925, 1997
  7. Tsukasa Matsumoto, Aki Ishiyama, Yuuichi Yamaguchi, Rokuro Masuma, Hideaki Ui, Kazuro Shiomi, Haruki Yamada, & Satoshi Omura: Novel cyclopentanone derivatives pentenocins A and B, with interleukin-1β converting enzyme inhibitory activity, produced by Trichoderma hamatum FO-6903. J. Antibiot., 52(8), 754-757, 1999
  8. Satoshi Omura, Hiroko Miyadera, Hideaki Ui, Kazuro Shiomi, Yuuichi Yamaguchi, Rokuro Masuma, Tohru Nagamitsu, Daisuke Takano, Toshiaki Sunazuka, Achim Harder, Heinz Kolbl, Michio Namikoshi, Hideto Miyoshi, Kimitoshi Sakamoto, & Kiyoshi Kita: An anthelmintic compound, nafuredin, shows selective inhibition of complex I in helminth mitochondria. Proc. Natl. Acad. Sci. USA, 98(1), 60-62, 2001
  9. Hideaki Ui, Kazuro Shiomi, Yuuichi Yamaguchi, Rokuro Masuma, Tohru Nagamitsu, Daisuke Takano, Toshiaki Sunazuka, Michio Namikoshi & Satoshi Omura: Nafuredin, a novel inhibitor of NADH-fumarate reductase, produced by Aspergillus niger FT-0554. J. Antibiot., 54(3), 234-238, 2001
  10. Daisuke Takano, Tohru Nagamitsu, Hideaki Ui, Kazuro Shiomi, Yuuichi Yamaguchi, Rokuro Masuma, Isao Kuwajima, & Satoshi Omura: Absolute configuration of nafuredin, a new specific NADH-fumarate reductase inhibitor. Tetrahedron Lett., 42(16), 3017-3020, 2001
  11. Daisuke Takano, Tohru Nagamitsu, Hideaki Ui, Kazuro Shiomi, Yuuichi Yamaguchi, Rokuro Masuma, Isao Kuwajima, & Satoshi Omura: Total synthesis of nafuredin, a selective NADH-fumarate reductase inhibitor. Org. Lett. 3(15), 2289-2291, 2001
  12. Kazuhiko Otoguro, Akiko Kohana, Chizu Manabe, Aki Ishiyama, Hideaki Ui, Kazuro Shiomi, Haruki Yamada, & Satoshi Omura: Potent antimalarial activities of polyether antibiotic, X-206. J. Antibiot., 54(8), 658-663, 2001
  13. Kazuhiko Otoguro, Aki Ishiyama, Hideaki Ui, Miyuki Kobayashi, Chizu Manabe, Guan Yan, Yoko Takahashi, Haruo Tanaka, Haruki Yamada, Satoshi Omura: In vitro and in vivo antimalarial activities of the monoglycoside polyether antibiotic, K-41 against drug resistant strains of Plasmodia. J. Antibiot., 55(9), 832-834, 2002
  14. Hiroko Miyadera, Kazuro Shiomi, Hideaki Ui, Yuichi Yamaguchi, Rokuro Masuma, Hiroshi Tomoda, Hideto Miyoshi, Arihiro Osanai, Kiyoshi Kita, and Satoshi Omura: Atpenins, potent and specific inhibitors of mitochondrial complexII (succinate-ubiquinone oxidoreductase). Proc. Natl. Acad. Sci. USA 100(2), 473-477, 2003
  15. Masaki Handa, Hideaki Ui, Daisuke Yamamoto, Soichi Monma, Yuzuru Iwai, Toshiaki Sunazuka, and Satoshi Omura: Structure determination of lustromycin, an antibiotic against anaerobic bacteria. Heterocycles 59(2), 497-500, 2003
  16. Kazuhiko Otoguro, Hideaki Ui, Aki Ishiyama, Noriko Arai, Miyuki Kobayashi, Yoko Takahashi, Rokuro Masuma, Kazuro Shiomi, Haruki Yamada, and Satoshi Omura: In vitro antimalarial activities of the microbial metabolites. J. Antibiot. 56(3), 322-324, 2003
  17. Tohru Nagamitsu, Daisuke Takano, Kazuro Shiomi, Hideaki Ui, Yuichi Yamaguchi, Rokuro Masuma, Yoshihiro Harigaya, Isao Kuwajima, and Satoshi Omura: Total synthesis of nafuredin-gamma, a gamma lactone related to nafuredin with selective inhibitory activity against NADH-fumarate reductase. Tetrahedron Lett. 44(34), 6441-6444, 2003
  18. Kazuhiko Otoguro, Hideaki Ui, Aki Ishiyama, Miyuki Kobayashi, Hideaki Togashi, Yoko Takahashi, Rokuro Masuma, Haruo Tanaka, Hiroshi Tomoda, Haruyuki Yamada, Satoshi Omura: In vitro and in vivo antimalarial activities of non-glycosidic 18-membered macrolide antibiotic, borrelidin, against drug-resistant strains of Plasmodia. J. Antibiot. 56(8), 727-729, 2003

[特許]

  1. 出願番号　　　　　特願2003-63769
    発明等の名称　　　マラリア原虫の感染予防・治療剤
    出願人　　　　　　（社）北里研究所
    発明者等の氏名　　大村　智、乙黒一彦、山田陽城、宇井英明