スタッフ紹介


　塩見　和朗（しおみ　かずろう）

shiomik@pharm.kitasato-u.ac.jp

経歴

1979.3：東京大学農学部農芸化学科卒業
1979.4：宝酒造（株）入社
1980.10−1988.3：（財）微生物化学研究所客員研究員
1988.2：農学博士（東京大学）
1990.4：宝酒造（株）退社
1990.5：北里研究所微生物薬品化学部
1991.4：北里研究所生物機能研究所天然物化学研究室室長代理
1997.4：北里研究所生物機能研究所天然物化学研究室室長
2001.4：北里大学北里生命科学研究所生物機能研究室助教授
2002.4：北里大学薬学部微生物薬品製造学教室助教授

主な研究テーマ

微生物の生産する抗生物質、特に抗寄生虫抗生物質の探索

教育・研究の抱負

世の中で使われる新しい薬を見つけたい

所属学会

日本薬学会、日本農芸化学会

主な業績

［学術論文 - 学会誌］

  1. K. Shiomi, H. Iinuma, M. Hamada, H. Naganawa, M. Manabe, C. Matsuki, T. Takeuchi, H. Umezawa: Novel antibiotics napyradiomycins. Production, isolation, physico-chemical properties and biological activity. J. Antibiot. 39, 487-493 (1986)
  2. H. Nakamura, K. Shiomi, H. Iinuma, H. Naganawa, T. Obata, T. Takeuchi, H. Umezawa, Y. Takeuchi, Y. Iitaka: Isolation and characterization of a new antibiotic, dioxapyrrolomycin, related to pyrrolomycins. J. Antibiot. 40, 899-903 (1987)
  3. K. Shiomi, H. Iinuma, H. Naganawa, M. Hamada, S. Hattori, H. Nakamura, T. Takeuchi, Y. Iitaka: New antibiotic produced by Micromonospora grobosa. J. Antibiot. 43, 1000-1005 (1990)
  4. K. Ikai, K. Shiomi, K. Takesako, I. Kato, H. Naganawa: NMR studies of aureobasidins A and E. J. Antibiot. 44, 1199-1207 (1991)
  5. D. Van Del Pyl, J. Inokoshi, K. Shiomi, H. Yang, H. Takeshima, S. Omura: Inhibition of farnesyl-protein transferase by gliotoxin and acetylgliotoxin. J. Antibiot. 45, 1802-1805 (1992)
  6. K. Shiomi, H. Yang, J. Inokoshi, D. Van Del Pyl, A. Nakagawa, H. Takeshima, S. Omura: Pepticinnamins, new farnesyl-protein transferase inhibitors produced by an actinomycete. II. Structural elucidation of pepticinnamin E. J. Antibiot. 46, 229-234 (1993)
  7. K. Shiomi, K. Haneda, H. Tomoda, Y. Iwai, S. Omura: Cytosaminomycins, new anticoccidial agents produced by Streptomyces sp. KO-8119. II. Structure elucidation of cytosaminomycins A, B, C and D. J. Antibiot. 47, 782-786 (1994)
  8. K. Shiomi, H. Yang, Q. Xu, N. Arai, M. Namiki, M. Hayashi, J. Inokoshi, H. Takeshima, R. Masuma, K. Komiyama, S. Omura: Phenopyrrozin, a new radical scavenger produced by Penicillium sp. FO-2047. J. Antibiot. 48, 1413-1418 (1995)
  9. K. Shiomi, R. Uchida, J. Inokoshi, H. Tanaka, Y. Iwai, S. Omura: Andrastins A~C, new protein farnesyltransferase inhibitors, produced by Penicillium sp. FO-3929. Tetrahedron Lett. 37, 1265-1268 (1996)
  10. N. Arai, K. Shiomi, S. Takamatsu, K. Komiyama, M. Shinose, Y. Takahashi,Y. Tanaka, Y. Iwai, J.-R. Liu, S. Omura: Amphistin, a new melanogenesis inhibitor, produced by an actinomycete. J. Antibiot. 50, 808-814 (1997)
  11. Y. Tanaka, K. Shiomi, K. Kamei, M. Sugoh-Hagino, Y. Enomoto, F. Fang, Y. Yamaguchi, R. Masuma, C. G. Zhang, X. W. Zhang, S. Omura: Antimalarial activity of radicicol, heptelidic acid and other fungal metabolites. J. Antibiot. 51, 153-160 (1998)
  12. S. Omura, Y. Enomoto, M. Shinose, Y. Takahashi, Y. Iwai, K. Shiomi: Isolation and structure of a new antibiotic viridomycin F produced by Streptomyces sp. K96-0188. J. Antibiot. 52, 61-64 (1999)
  13. K. Shiomi, N. Arai, Y. Iwai, A. Turberg, H. Kolbl, S. Omura: Structure of argifin, a new chitinase inhibitor produced by Gliocladium sp. FTD-0668. Tetrahedron Lett. 41, 2141-2143 (2000)
  14. S. Omura, N. Arai, Y. Yamaguchi, R. Masuma, Y. Iwai, M. Namikoshi, A. Turberg, H. Kolbl, K. Shiomi: Argifin, a new chitinase inhibitor, produced by Gliocladium sp. FTD-0668. I. Taxonomy, fermentation, and biological activities. J. Antibiot. 53, 603-608 (2000)
  15. N. Arai, K. Shiomi, Y. Iwai, S. Omura: Argifin, a new chitinase inhibitor, produced by Gliocladium sp. FTD-0668. II. Isolation, physico-chemical properties, and structure elucidation. J. Antibiot. 53, 609-614 (2000)
  16. N. Arai, K. Shiomi, Y. Yamaguchi, R. Masuma, Y. Iwai, A. Turberg, H. Kolbl, S. Omura: Argadin, a new chitinase inhibitor, produced by Clonostachys sp. FO-7314. Chem. Pharm. Bull. 48, 1442-1446 (2000)
  17. S. Omura, H. Miyadera, H. Ui, K. Shiomi, Y. Yamaguchi, R. Masuma, T. Nagamitsu, D. Takano, T. Sunazuka, A. Harder, H. Kolbl, M. Namikoshi, H. Miyoshi, K. Kita: An anthelmintic compound, nafuredin, shows selective inhibition of complex I in helminth mitochondria. Proc. Natl. Acad. Sci. USA 98, 60-62 (2001)
  18. H. Ui, K. Shiomi, Y. Yamaguchi, R. Masuma, T. Nagamitsu, D. Takano, T. Sunazuka, M. Namikoshi, S. Omura: Nafuredin, a novel inhibitor of NADH-fumarate reductase, produced by Aspergillus niger FT-0554. J. Antibiot. 54, 234-238 (2001)
  19. Y. Enomoto, K. Shiomi, A. Matsumoto, Y. Takahashi, Y. Iwai, A. Harder, H. Kolbl, H. B. Woodruff, S. Omura: Isolation of a new antibiotic oligomycin G produced by Streptomyces sp. WK-6150. J. Antibiot. 54, 308-313 (2001)
  20. D. Takano, T. Nagamitsu, H. Ui, K. Shiomi, Y. Yamaguchi, R. Masuma, I. Kuwajima, S. Omura: Absolute configuration of nafuredin, a new specific NADH-fumarate reductase inhibitor. Tetrahedron Lett. 42, 3017-3020 (2001)
  21. D. Takano, T. Nagamitsu, H. Ui, K. Shiomi, Y. Yamaguchi, R. Masuma, I. Kuwajima, S. Omura: Total synthesis of nafuredin, a selective NADH-fumarate reductase inhibitor. Org Lett. 3, 2289-2291 (2001)
  22. K. Otoguro, A. Kohana, C. Manabe, A. Ishiyama, H. Ui, K. Shiomi, H. Yamada, S. Omura: The potent effects of X-206 on Plasmodium falciparum in vitro and Plasmodium bergei in vivo. J. Antibiot. 54, 658-663 (2001)
  23. D. R. Houston, K. Shiomi, N. Arai, S. Omura, M. G. Peter, A. Turberg, B. Synstad, V. G .H. Eijsink, D. M. F. van Aalten: High resolution structures of chitinase complexed with natural product cyclopentapeptide inhbitors: Mimicry of carbohydrate substrate. Proc. Natl. Acad. Sci. USA 99, 9127-9132 (2002)

［学術論文 - その他］

  1. K. Shiomi, H. Tomoda, K. Otoguro, S. Omura: Meroterpenoids with various biological activities produced by fungi. Pure Appl. Chem. 71, 1059-1064 (1999)
  2. 塩見和朗, 宇井英明, 大村 智: 新規抗寄生虫物質 nafuredin とその標的. バイオサイエンスとインダストリー 59, 465-466 (2001)

［著書］

  1. H. Tanaka, K. Kawakita, N. Imamura, K. Tsuzuki, K. Shiomi: General screening of enzyme inhibitors. In The Search for Bioactive Compounds from Microorganisms. Ed., S. Omura, pp. 117-160, Springer-Verlag, New York (1992)
  2. A. Turberg, I. Schroder, V. Gutsmann, N. Arai, K. Shiomi, S. Omura: Novel inhibitors of insect chitinases. In Chitin and Chitosan ―Chitin and Chitosan in Life Science―. Ed., T. Uragami, K. Kurita, T. Fukamizo, pp. 440-442, Kodansha Scientific Ltd., Tokyo (2001)
  3. K. Shiomi, S. Omura: Discovery of new macrolides. In Macrolide Antibiotics. Chemistry, Biology, and Practice. Second Edition. Ed., S. Omura, pp. 1-56, Academic Press, San Diego (2002)

［学会発表 - 特別講演］

  1. K. Shiomi, S. Omura: Protein farnesyltransferase inhibitors from microbial products. 5th International Conference on Chemical Synthesis of Antibiotics and Related Microbial Products (Book of Abstracts), IL-11 (1996) [Debrecen, Hungary]
  2. 塩見和朗, 大村 智: 微生物由来の生物活性物質. 第34回植物化学シンポジウム講演要旨集, 1-10 (1998) [東京]
  3. K. Shiomi, H. Tomoda, K. Otoguro, S. Omura: Meroterpenoids with various biological activities produced by fungi. Abstracts of 21st IUPAC International Symposium on the Chemistry of Natural Products, 22 (1998) [Beijing, China]